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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T8055 TFEB activator 1

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,(1E,4E)-1,5(2 -甲氧基苯基)-1,4-戊二烯-3-酮,RPN77612

Others; Autophagy Autophagy; Others
TFEB activator 1 (Curcumin analog compound C1) 是转录因子 EB 的一种激活剂,有望预防或治疗阿尔茨海默病。
T39459 THZ-P1-2

THZ-P1-2

THZ-P1-2 is a novel, specific inhibitor of PI5P4K that effectively targets PI5P4Kα. With an IC 50 of 190 nM, THZ-P1-2 selectively inhibits PI5P4Kα by forming covalent bonds with cysteine residues located on a disordered loop present in PI5P4Kα/β/γ. This mechanism not only disrupts autophagy but also elevates TFEB signaling. Moreover, THZ-P1-2 exhibits potent anticancer effects in leukemia cell lines, making it a promising candidate for therapeutic applications.

化合物

TFEB activator 1
Cat.No: T8055
Synonym: (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,(1E,4E)-1,5(2 -甲氧基苯基)-1,4-戊二烯-3-酮,RPN77612
Target: Others, Autophagy
THZ-P1-2
Cat.No: T39459
Synonym: THZ-P1-2
Target:
Cat. No. Product Name Target Signaling Pathways
T5689 20-DEOXYINGENOL

Others; Autophagy Autophagy; Others
20-Deoxyingenol 是从甘遂的根中分离出的一种二萜类天然产物。它可通过促进体外转录因子 EB 的核易位来促进自噬和溶酶体生物发生,可研究骨关节炎。

天然产物

20-DEOXYINGENOL
Cat.No: T5689
Synonym:
Target: Others, Autophagy
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