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Cat. No.	Product Name	Target	Signaling Pathways
T36782	TAK1-IN-2 TAK1-IN-2
	TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1]. TAK1-IN-2 (compound 54) (10 μM) has no effect on cell viability in TNF-α stimulated HCT-15 cells[1]. [1]. Veerman JJN, et, al. Discovery of 2,4-1 H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. ACS Med Chem Lett. 2021 Mar 3;12(4):555-562.
T77091	Modakafusp alfa
	Modakafusp alfa (TAK-573) 是一种融合蛋白，由人源化抗CD38 IgG4 单克隆抗体和2个减毒IFNα2b分子组成。该化合物主要用于多发性骨髓瘤的研究。
T78636	Firazorexton hydrate TAK-994
	Firazorexton hydrate (TAK-994)为一种高效的食欲素2型受体(OX2R)激动剂，EC50值为19 nM。在发作性睡病小鼠模型中，该化合物能够有效减少觉醒碎片和猝倒样发作的发生。
T35438	(5E)-7-Oxozeaenol
	(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 μM, respectively.2 \|1. Fakhouri, L., El-Elimat, T., Hurst, D.P., et al. Isolation, semisynthesis, covalent docking and transforming growt...
T77084	Mezagitamab
	Mezagitamab (TAK-079) 是一种 IgG1λ 类型的抗CD38单克隆抗体。其通过促进抗体和补体依赖性的细胞毒性，来耗尽表达CD38的肿瘤细胞，显示出在复发/难治性多发性骨髓瘤 (RRMM) 及原发性血小板减少性紫癜 (ITP) 等疾病中的治疗潜力。