Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10589 |
BPN-15606 besylate (1914989-49-3 free base)
BPN-15606 besylate |
Others | Others |
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator, attenuates the production of Aβ40 and Aβ42 by SHSY5Y neuroblastoma cells (IC50s: 7 nM and 17nM). | |||
T64081 | BPN-15606 besylate | ||
BPN-15606 besylate 是一种高效的、口服具有活力的 γ-secretase 调节剂 (GSM),能够减少 SHSY5Y 神经母细胞瘤细胞产生 Aβ42 (IC50: 7 nM) 和 Aβ40 (IC50: 17 nM) 的作用。BPN-15606 besylate 能够减少大鼠和小鼠中枢神经系统中的 Aβ42 和 Aβ40 水平。BPN-15606 besylate 表现出良好的 PK/PD 特性(包括生物利用度,半衰期和清除率)。 | |||
T10589L |
BPN-15606
|
Others | Others |
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavai |