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Search Results for " sphingomyelin "

25

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35805	C16 Sphingomyelin (d18:1/16:0) Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin	Endogenous Metabolite	Metabolism
	C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物，可用于研究生物膜的活性。
T38286	C26 Sphingomyelin (d18:1/26:0) C26 Sphingomyelin (d18:1/26:0)
	C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi...
T38182	C17 Sphingomyelin (d18:1/17:0) C17 Sphingomyelin (d18:1/17:0)
	C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.
T36860	C22 Sphingomyelin (d18:1/22:0) C22 Sphingomyelin (d18:1/22:0)
	C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin .
T35809	C20 Sphingomyelin (d18:1/20:0)
	C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m...
T36149	13C C16 Sphingomyelin (d18:1/16:0)
	13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or...
T76156	Sphingomyelin phosphodiesterase
	Sphingomyelinphosphodiesterase 是一种水解酶，参与鞘磷脂代谢过程。Sphingomyelinphosphodiesterase 水解鞘磷脂，使其向磷酸胆碱和神经酰胺转化。Sphingomyelinphosphodiesterase 还在细胞分化、各种免疫和炎症反应以及细胞内胆固醇运输和代谢中发挥重要作用。
T75371	C12 NBD Sphingomyelin
	C12 NBD sphingomyelin 是一种具有活性的sphingomyelin 衍生物，带有荧光 C12 硝基苯并恶二唑 (C12 NBD)。C12 NBD sphingomyelin 可用作研究鞘磷脂酶代谢和转运的底物 (Ex=470 nm，Em=525 nm)。
T8734	Choline	Others	Others
	Choline hydroxide 是一种普遍存在的水溶性营养素，通常与 B 族维生素有关。
T74687	N-Stearoylsphingomyelin
	N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin) 为抑制磷脂酶 Cδ1 (PLCδ1) 的鞘磷脂类化合物。
T38000	Lysosphingomyelin (d18:1)
	Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the acylated group of sphingomyelin by a deacylase. Lysosphingomyelin may, in turn, serve as a substrate for autotaxin, which removes choline to produce sphingosine-1-phosphate. The receptors and signaling pathways that are activated by lyso-sphingosine are diverse and vary between ...
T37187	D-erythro/L-threo Lysosphingomyelin (d18:1) D-erythro/L-threo Lysosphingomyelin (d18:1)
	Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O...
T37953	Sphingomyelins (buttermilk)
	Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling...
T38452	L-threo Lysosphingomyelin (d18:1) L-threo-Sphingosylphosphorylcholine,L-threo Lysosphingomyelin (d18:1)
	L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is a naturally occurring bioactive sphingolipid. It acts as a potent agonist for S1P receptors, with EC50 values of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively.
T15044	D609	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	D609 (Tricyclodecan-9-yl-Xanthogenate) 具有广泛的生物活性，包括抗氧化、抗凋亡、抗胆碱能、抗肿瘤、抗炎、抗病毒、抗增殖和神经保护活性。D609 通过引起磷脂酰胆碱 (PC) 特异性磷脂酶 C (PC-PLC) 和鞘磷脂合酶 (SMS) 的竞争性抑制来发挥作用。
T15822	Ly93	Others	Others
	Ly93 是一种具有选择性和口服活性的鞘磷脂合成酶 2（SMS2）抑制剂（IC50：91 nM），可用于研究动脉粥样硬化。
T12937	SMS1-IN-1	Others	Others
	SMS1-IN-1 是一种有效的鞘磷脂合成酶1 (SMS1, IC50 = 2.1 μM) 抑制剂，可用于动脉粥样硬化研究。
T7263	SMS2-IN-2 SMS2 inhibitors	Others	Others
	SMS2-IN-2 (SMS2 inhibitors) 是一种具有高度选择性、口服具有活力的鞘磷脂合成酶 2 抑制剂，能够作用于 SMS2 (IC50:100 nM)和 SMS1 (IC50:56 nM)。它可减轻慢性炎症反应。
T69351	AD2765
	AD2765, also known as AD 2845 and Sphingosylphosphoryl choline, is a novel thiourea derivative of sphingomyelin that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death.
T36188	Ceramide Phosphoethanolamines (bovine)
	Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi...
T12938	SMS2-IN-1	Others	Others
	SMS2-IN-1 是一种有效且具有高选择性的鞘磷脂合成酶 2 (SMS2) 抑制剂， IC50 为 6.5 nM，Kd 为 37 nM。SMS2-IN-1 对 SMS2 的选择性比 SMS1 (IC50 为 1000 nM) 多 150 倍。
T35423	7-oxo Staurosporine
	7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits gr...
T78461	C6 NBD Ceramide Nbd-ceramide
	C6 NBD Ceramide 是一种细胞膜渗透性高尔基体荧光探针（Ex=466 nm, Em=536 nm），是一种带有绿色荧光标记的神经酰胺，可识别活体及固定细胞的高尔基体，观测活细胞中高尔基体形态变化。C6 NBD Ceramide 在细胞内可代谢生成荧光鞘磷脂和葡糖基甘油酰胺，从而应用于鞘脂转运和代谢机制研究。
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...
T37455	C18 D-threo Ceramide (d18:1/18:0) C18 D-threo Ceramide (d18:1/18:0)
	C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas...

化合物

C16 Sphingomyelin (d18:1/16:0)

Cat.No: T35805

Synonym: Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin

Target: Endogenous Metabolite

C26 Sphingomyelin (d18:1/26:0)

Cat.No: T38286

Synonym: C26 Sphingomyelin (d18:1/26:0)

C17 Sphingomyelin (d18:1/17:0)

Cat.No: T38182

Synonym: C17 Sphingomyelin (d18:1/17:0)

C22 Sphingomyelin (d18:1/22:0)

Cat.No: T36860

Synonym: C22 Sphingomyelin (d18:1/22:0)

C20 Sphingomyelin (d18:1/20:0)

Cat.No: T35809

13C C16 Sphingomyelin (d18:1/16:0)

Cat.No: T36149

Sphingomyelin phosphodiesterase

Cat.No: T76156

C12 NBD Sphingomyelin

Cat.No: T75371

Cat.No: T8734

Target: Others

N-Stearoylsphingomyelin

Cat.No: T74687

Lysosphingomyelin (d18:1)

Cat.No: T38000

D-erythro/L-threo Lysosphingomyelin (d18:1)

Cat.No: T37187

Synonym: D-erythro/L-threo Lysosphingomyelin (d18:1)

Sphingomyelins (buttermilk)

Cat.No: T37953

L-threo Lysosphingomyelin (d18:1)

Cat.No: T38452

Synonym: L-threo-Sphingosylphosphorylcholine,L-threo Lysosphingomyelin (d18:1)

Cat.No: T15044

Target: Apoptosis, Antioxidant

Cat.No: T15822

Target: Others

Cat.No: T12937

Target: Others

Cat.No: T7263

Synonym: SMS2 inhibitors

Target: Others

Cat.No: T69351

Ceramide Phosphoethanolamines (bovine)

Cat.No: T36188

Cat.No: T12938

Target: Others

7-oxo Staurosporine

Cat.No: T35423

C6 NBD Ceramide

Cat.No: T78461

Synonym: Nbd-ceramide

Nicotinamide-d4

Cat.No: T69395

C18 D-threo Ceramide (d18:1/18:0)

Cat.No: T37455

Synonym: C18 D-threo Ceramide (d18:1/18:0)

Cat. No.	Product Name	Target	Signaling Pathways
TQ0312	Sphingomyelin	Endogenous Metabolite	Metabolism
	Sphingomyelin is a natural sphingolipid that existed in animal cell membranes. It implicates the regulation of transmembrane signaling.
TN6772	Malabaricone C	Others	Others
	Malabaricone C 是天然的鞘磷脂合成酶抑制剂，对 SMS 1 和 SMS 2 的IC50分别为 3 和 1.5 μM。
T78473	Sphingosine (d17:1) C17 Sphingosine
	Sphingosine (d17:1) (C17 Sphingosine)是一种存在于人类皮肤中的17碳鞘脂，可被鞘氨醇激酶的磷酸化。Sphingosine C-17作为内标可用于进行鞘脂类化合物的光谱分析。
T4944	Nervonic acid cis-15-Tetracosenoic acid,神经酸,Selacholeic acid	Endogenous Metabolite	Metabolism
	Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。
T1208	Citicoline sodium Citicoline sodium salt,CDP-choline,胞磷胆碱钠	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。

天然产物

Sphingomyelin

Cat.No: TQ0312

Target: Endogenous Metabolite

Cat.No: TN6772

Target: Others

Sphingosine (d17:1)

Cat.No: T78473

Synonym: C17 Sphingosine

Cat.No: T4944

Synonym: cis-15-Tetracosenoic acid,神经酸,Selacholeic acid

Target: Endogenous Metabolite

Citicoline sodium

Cat.No: T1208

Synonym: Citicoline sodium salt,CDP-choline,胞磷胆碱钠

Target: Apoptosis, Others, Endogenous Metabolite

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