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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T12916 Silvestrol aglycone

Others Others
Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.
T12915 Silvestrol aglycone (enantiomer)

Others Others
Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol.
T72943 eIF4A3-IN-17

eIF4A3-IN-17 是 silvestrol 类似物。eIF4A3-IN-17 干扰 eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50值分别为 0.9,15 和 1.8 nM。eIF4A3-IN-17 可用于人类肿瘤发病机制的研究。
T73001 eIF4A3-IN-9

eIF4A3-IN-9 是silvestrol 类似物。eIF4A3-IN-9 干扰eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 29,450 和 80 nM。eIF4A3-IN-9 可用于人类肿瘤发病机制的研究。
T72944 eIF4A3-IN-18

eIF4A3-IN-18 是silvestrol 类似物。eIF4A3-IN-18 干扰eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 0.8、35 和 2 nM。eIF4A3-IN-18 对 RMPI-8226 细胞具有细胞毒性,LC50值为 0.06 nM。eIF4A3-IN-18 可用于人类肿瘤发病机制的研究。

化合物

Silvestrol aglycone
Cat.No: T12916
Synonym:
Target: Others
Silvestrol aglycone (enantiomer)
Cat.No: T12915
Synonym:
Target: Others
eIF4A3-IN-17
Cat.No: T72943
Synonym:
Target:
eIF4A3-IN-9
Cat.No: T73001
Synonym:
Target:
eIF4A3-IN-18
Cat.No: T72944
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T16884 Silvestrol

(-)-Silvestrol

Others Others
Silvestrol is a eukaryotic translation initiation factor 4A inhibitor. Silvestrol causes autophagy and caspase-mediated apoptosis.
T11215 Episilvestrol

Others Others
Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris.

天然产物

Silvestrol
Cat.No: T16884
Synonym: (-)-Silvestrol
Target: Others
Episilvestrol
Cat.No: T11215
Synonym:
Target: Others
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