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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12916 |
Silvestrol aglycone
|
Others | Others |
Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity. | |||
T12915 |
Silvestrol aglycone (enantiomer)
|
Others | Others |
Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol. | |||
T72943 | eIF4A3-IN-17 | ||
eIF4A3-IN-17 是 silvestrol 类似物。eIF4A3-IN-17 干扰 eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50值分别为 0.9,15 和 1.8 nM。eIF4A3-IN-17 可用于人类肿瘤发病机制的研究。 | |||
T73001 |
eIF4A3-IN-9
|
||
eIF4A3-IN-9 是silvestrol 类似物。eIF4A3-IN-9 干扰eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 29,450 和 80 nM。eIF4A3-IN-9 可用于人类肿瘤发病机制的研究。 | |||
T72944 |
eIF4A3-IN-18
|
||
eIF4A3-IN-18 是silvestrol 类似物。eIF4A3-IN-18 干扰eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 0.8、35 和 2 nM。eIF4A3-IN-18 对 RMPI-8226 细胞具有细胞毒性,LC50值为 0.06 nM。eIF4A3-IN-18 可用于人类肿瘤发病机制的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16884 |
Silvestrol
(-)-Silvestrol |
Others | Others |
Silvestrol is a eukaryotic translation initiation factor 4A inhibitor. Silvestrol causes autophagy and caspase-mediated apoptosis. | |||
T11215 |
Episilvestrol
|
Others | Others |
Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris. |