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Cat. No.	Product Name	Target	Signaling Pathways
T13510	Sigma-LIGAND-1	Sigma receptor	GPCR/G Protein
	Sigma-LIGAND-1 是一种选择性 sigma 受体配体，在 DTG 和 PPP 位点的 IC50 分别为 16 nM，19 nM。Sigma-LIGAND-1 对多巴胺 D2 受体的 Ki 为 4000 nM。
T63048	Sigma-LIGAND-1 hydrochloride
	Sigma-LIGAND-1 hydrochloride 是一种选择性 sigma 受体配体，能够作用于 DTG (IC50: 16 nM) 和 PPP (IC50: 19 nM) 位点。Sigma-LIGAND-1 hydrochloride 能够作用于多巴胺 D2受体 (Ki: 4000 nM)。
T39211	PD 144418 oxalate	Sigma receptor	GPCR/G Protein
	PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity.
T50090	3-(2-phenylethynyl)pyridine	Others	Others
	3-(2-phenylethynyl)pyridine 是一种吡啶衍生物，是人体中各种受体的配体，包括多巴胺 D2受体、sigma-1受体和5-HT6受体，已被研究用于治疗各种神经疾病，包括精神分裂症、抑郁症和阿尔茨海默病。
T26100	RLH 033 RLH033,RLH-033
	RLH 033 is a selective ligand for the sigma 1 recognition site.
T25584	KSCM-1 KSCM 1
	KSCM-1 is a selective sigma-1 receptor ligand.
T61846	CM398
	CM398 is an orally active chemical compound that acts as a highly selective ligand for the sigma-2 receptor (K i =0.43 nM), demonstrating a significant ratio of selectivity between sigma-1 and sigma-2 receptors (1000-fold). Moreover, CM398 exhibits notable affinity towards dopamine (K i =32.90 nM) and serotonin transporters (K i =244.2 nM). In addition, CM398 has shown promising efficacy as an anti-inflammatory analgesic in a mouse model of inflammatory pain induced by formalin [1].
T16445	PD 144418	Sigma receptor	GPCR/G Protein
	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significant affinity for other receptors, ion channels, and enzymes.

化合物

Sigma-LIGAND-1

Cat.No: T13510

Target: Sigma receptor

Sigma-LIGAND-1 hydrochloride

Cat.No: T63048

PD 144418 oxalate

Cat.No: T39211

Target: Sigma receptor

3-(2-phenylethynyl)pyridine

Cat.No: T50090

Target: Others

Cat.No: T26100

Synonym: RLH033,RLH-033

Cat.No: T25584

Synonym: KSCM 1

Cat.No: T61846

Cat.No: T16445

Target: Sigma receptor

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