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9

抑制剂 & 化合物

1

化合物库

3

重组蛋白

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Cat. No.	Product Name
L3700	JAK-STAT 化合物库		252 compounds
	252 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；

化合物库

JAK-STAT 化合物库

Cat.No: L3700

Compounds: 252

Cat. No.	Product Name	Target	Signaling Pathways
T70148	CDK8-IN-4k
	CDK8-IN-4k is a potent and highly selective CDK8 inhibitor, with no apparent potential for time-dependent CYP3A4 inhibition.
T24838	Stafib-1 Stafib 1,Stafib1	STAT	JAK/STAT signaling; Stem Cells
	Stafib-1 是一种特异性的 STAT5β 抑制剂，靶向 SH2 结构域，IC50 为 154 nM，Ki 为 44 nM。
T9646	Stafib-2	STAT	JAK/STAT signaling; Stem Cells
	Stafib-2 是一种转录因子 STAT5b 抑制剂，具有有效性和选择性。Stafib-2 对STAT5b 和 STAT5a 有抑制作用， IC50 值分别为 82 nM 和 1.7 μM。Stafib-2 的细胞通透性较差。
T9339	Stafia-1	STAT	JAK/STAT signaling; Stem Cells
	Stafia-1 是STAT5a 抑制剂，Ki 为 10.9 μM，IC50 为 22.2 μM。它与 STAT5b 和其他 STAT 家族成员相比，显示出高选择性。
T73739	Pomstafib-2
	Pomstafib-2 是一种有效的选择性 STAT5b 抑制剂。Pomstafib-2 降低 pSTAT5b 的表达并诱导细胞凋亡 (Apoptosis)。
T70150	Capstafin
	Capstafin is a highly potent and selective inhibitor of STAT5b.
T70149	PomCapstafin
	PomCapstafin is a prodrug of Capstafin, acting as a potent, selective STAT5b inhibitor.
T71156	Poloxipan
	Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.
T62496	IST5-002
	IST5-002 是一种 Stat5a/b 的有效抑制剂，能够选择性地抑制 Stat5a/b 的转录活性，对 Stat5a 和 Stat5b 的 IC50 值分别为 1.5 μM 和 3.5 μM。IST5-002 能够诱导前列腺癌细胞和慢性粒细胞白血病 (CML) 细胞凋亡 (apoptotic) 及死亡。IST5-002 能够用于研究前列腺癌和慢性粒细胞白血病 (CML)。

化合物

Cat.No: T70148

Cat.No: T24838

Synonym: Stafib 1,Stafib1

Target: STAT

Cat.No: T9646

Target: STAT

Cat.No: T9339

Target: STAT

Cat.No: T73739

Cat.No: T70150

Cat.No: T70149

Cat.No: T71156

Cat.No: T62496

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01003	STAT5B Protein, Human, Recombinant (His) Signal Transducer and Activator of Transcription 5B...	Human	E. coli
	Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adul...
TMPU-00004	STAT5A Protein, Human, Recombinant (His) MGF,Signal transducer and activator of transcription 5A	Human	E. coli
	Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. Many studies have indicated a key role of STAT5a in leukemia, breast, colon, head and neck, and prostate cancer. Until recently, the unique characteristics and function of STAT5a in these cancers have not been delineated from STAT5b, and more research into their differential behavior is warranted. Because of its integral role in immune cell development, STAT5a may contribute to tumor de...
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...

重组蛋白

STAT5B Protein, Human, Recombinant (His)

Cat.No: TMPJ-01003

Species: Human

Expression System: E. coli

STAT5A Protein, Human, Recombinant (His)

Cat.No: TMPU-00004

Species: Human

Expression System: E. coli

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

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