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Search Results for " smad4 "

Targets Recommended: TGF-beta/Smad

3

抑制剂 & 化合物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L4100	TGF-β/Smad靶点化合物库		184 compounds
	184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

TGF-β/Smad靶点化合物库

Cat.No: L4100

Compounds: 184

Cat. No.	Product Name	Target	Signaling Pathways
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T78798	MY-673
	MY-673是CBSI（秋水仙碱结合位点抑制剂），可抑制微管蛋白聚合。该化合物还可阻断ERK信号通路，进而调节TGF-β/SMAD通路中的SMAD4蛋白表达。MY-673已经证实能在体内外有效抑制细胞的增殖和迁移，同时诱导apoptosis（细胞凋亡）。
T71252	PC-046
	PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di...

化合物

Cat.No: T1748

Synonym: KGN

Target: TGF-beta/Smad

Cat.No: T78798

Cat.No: T71252

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01108	SMAD4 Protein, Human, Recombinant (His) DPC4,SMAD 4,Deletion Target in Pa...	Human	E. coli
	SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumo...
TMPH-02055	RBPMS Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. RBPMS Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-...
TMPJ-00271	SMAD3 Protein, Human, Recombinant (His & Flag) SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,J...	Human	E. coli
	Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated...
TMPH-01699	SMAD2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3...
TMPY-03291	SMAD2 Protein, Mouse, Recombinant (His & GST) mMad2,Smad-2,7120426M23Rik,Madr2,Madh2,	Mouse	Baculovirus Insect Cells
	SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein...
TMPH-01702	SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory gen...
TMPY-02444	ATF2 Protein, Human, Recombinant (His & GST) CREB2,CRE-BP1,CREB-2,TREB7,activating transcription factor 2...	Human	Baculovirus Insect Cells
	Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has ...
TMPY-03419	SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) SMAD family member 3	Human,Mouse,Rat	Baculovirus Insect Cells
	SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice,...
TMPY-04468	STK16 Protein, Human, Recombinant (His & NusA) MPSK,serine/threonine kinase 16,TSF1,KRCT,PKL12	Human	E. coli
	Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 / MPSK1 belongs to the protein kinase superfamily and Ser/Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or c...

重组蛋白

SMAD4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01108

Species: Human

Expression System: E. coli

RBPMS Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02055

Species: Human

Expression System: E. coli

SMAD3 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00271

Species: Human

Expression System: E. coli

SMAD2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01699

Species: Human

Expression System: E. coli

SMAD2 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-03291

Species: Mouse

Expression System: Baculovirus Insect Cells

SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-01702

Species: Human

Expression System: E. coli

ATF2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02444

Species: Human

Expression System: Baculovirus Insect Cells

SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)

Cat.No: TMPY-03419

Species: Human,Mouse,Rat

Expression System: Baculovirus Insect Cells

STK16 Protein, Human, Recombinant (His & NusA)

Cat.No: TMPY-04468

Species: Human

Expression System: E. coli

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