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Cat. No. | Product Name | Target | Signaling Pathways |
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T12902 |
SHMT-IN-1
|
Others | Others |
SHMT-IN-1 是有效的血浆丝氨酸羟甲基转移酶 (SHMT) 抑制剂。SHMT-IN-1 具有抗肿瘤活性。 | |||
T62404 |
SHMT-IN-2
|
Others | Others |
SHMT-IN-2 (compound 2) 是一种特异性人 SHMT1/2 小分子抑制剂,能够作用于 SHMT1 (IC50: 13 nM) 和 SHMT2 (IC50: 66 nM)。SHMT-IN-2 对许多人类癌细胞的生长具有抑制作用,对 B 细胞淋巴瘤具有敏感性。 | |||
T72984 |
(Rac)-SHIN2
|
Others | Others |
(Rac)-SHIN2 是一种丝氨酸羟甲基转移酶 (SHMT) 抑制剂,可提高 NOTCH1 驱动的小鼠原代 T-ALL 在体内的存活率,可用于研究 T 细胞急性淋巴细胞白血病 (T-ALL)。 | |||
T73358 |
(-)SHIN2
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(-)SHIN2 是 (+)SHIN2 的异构体。(+)SHIN2 是丝氨酸羟甲基转移酶 (SHMT) 的抑制剂,具有抗白血病作用。(+)SHIN2 与 Methotrexate 在体内异种移植模型中具有协同作用。 | |||
T36396 |
D-Homoserine lactone
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D-homoserine lactone is an enantiomer of L-homoserine lactone and an inhibitor of serine hydroxymethyltransferase (SHMT; Ki= 11 mM for the rabbit enzyme).1 1.Wang, E.A., Kallen, R., and Walsh, C.Mechanism-based inactivation of serine transhydroxymethylases by D-fluoroalanine and related amino acidsJ. Biol. Chem.256(13)6917-6926(1981) |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00484 |
SHMT1 Protein, Human, Recombinant (His)
Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd... |
Human | HEK293 Cells |
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ... |