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Search Results for " shmt "
Targets Recommended: Others

5

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T12902 SHMT-IN-1

Others Others
SHMT-IN-1 是有效的血浆丝氨酸羟甲基转移酶 (SHMT) 抑制剂。SHMT-IN-1 具有抗肿瘤活性。
T62404 SHMT-IN-2

Others Others
SHMT-IN-2 (compound 2) 是一种特异性人 SHMT1/2 小分子抑制剂,能够作用于 SHMT1 (IC50: 13 nM) 和 SHMT2 (IC50: 66 nM)。SHMT-IN-2 对许多人类癌细胞的生长具有抑制作用,对 B 细胞淋巴瘤具有敏感性。
T72984 (Rac)-SHIN2

Others Others
(Rac)-SHIN2 是一种丝氨酸羟甲基转移酶 (SHMT) 抑制剂,可提高 NOTCH1 驱动的小鼠原代 T-ALL 在体内的存活率,可用于研究 T 细胞急性淋巴细胞白血病 (T-ALL)。
T73358 (-)SHIN2

(-)SHIN2 是 (+)SHIN2 的异构体。(+)SHIN2 是丝氨酸羟甲基转移酶 (SHMT) 的抑制剂,具有抗白血病作用。(+)SHIN2 与 Methotrexate 在体内异种移植模型中具有协同作用。
T36396 D-Homoserine lactone

D-homoserine lactone is an enantiomer of L-homoserine lactone and an inhibitor of serine hydroxymethyltransferase (SHMT; Ki= 11 mM for the rabbit enzyme).1 1.Wang, E.A., Kallen, R., and Walsh, C.Mechanism-based inactivation of serine transhydroxymethylases by D-fluoroalanine and related amino acidsJ. Biol. Chem.256(13)6917-6926(1981)

化合物

SHMT-IN-1
Cat.No: T12902
Synonym:
Target: Others
SHMT-IN-2
Cat.No: T62404
Synonym:
Target: Others
(Rac)-SHIN2
Cat.No: T72984
Synonym:
Target: Others
(-)SHIN2
Cat.No: T73358
Synonym:
Target:
D-Homoserine lactone
Cat.No: T36396
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-00484 SHMT1 Protein, Human, Recombinant (His)

Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd...

Human HEK293 Cells
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ...

重组蛋白

SHMT1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00484
Species: Human
Expression System: HEK293 Cells
TargetMol Loading
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