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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T64229 | SENP2-IN-1 | ||
SENP2-IN-1 是一种选择性的 SENP2 抑制剂。SENP2-IN-1 能够抑制 SENP1 (IC50: 1.3 μM)、SENP2 (IC50: 0.69 μM) 和 SENP5 (IC50: 22.7 μM)。SENP2-IN-1 能够用于研究癌症。 | |||
T3951 |
NSC632839
F6,Ubiquitin Isopeptidase Inhibitor II |
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) 是一种非选择性异肽酶抑制剂,可抑制USP2、USP7和SENP2,EC50分别为 45±4 μM、37±1 μM 和 9.8±1.8 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01336 |
SENP2 Protein, Human, Recombinant
Sentrin/SUMO-specific protease SENP2,Axam<... |
Human | E. coli |
SENP2 is an enzyme that belongs to the peptidase C48 family. SENP2 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. It has been implicated as a down-regulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. | |||
TMPY-02391 |
SUMO1 Protein, Human, Recombinant (His)
small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,S... |
Human | E. coli |
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act... |