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Cat. No.	Product Name	Target	Signaling Pathways
T18680	SD-36	Others; PROTACs	Others; PROTAC
	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their transcriptional activity (IC50=10 nM). The compound, consisting of the STAT3 inhibitor SI-109, a linker, and a CRBN ligand Lenalidomide analog for E3 ubiquitin ligase[1], demonstrates significant anti-tumor effects and achieves complete, long-lasting tumor regression in mouse mod...
T18064	Lenalidomide-Br	Ligand for E3 Ligase	PROTAC
	Lenalidomide-Br是Lenalidomide的衍生物，作为cereblon (CRBN)的配体，后者是参与蛋白质招募的E3泛素连接酶。通过连接器，Lenalidomide-Br可与蛋白质配体偶联，构建PROTACs。例如，Lenalidomide-Br被作为PROTAC STAT3降解剂SD-36的组成部分利用。