Cat. No. | Product Name | Target | Signaling Pathways |
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T7277 |
SB 242084
6 - 氯-2,3 - 二氢- 5 -甲基- N - [6 - [(2 - 甲基-3 - 吡啶基)氧] -3 - 吡啶基] - 1H -吲哚- 1 - 酰胺盐酸盐,SB 242084 dihydrochloride hydrate |
5-HT Receptor | GPCR/G Protein; Neuroscience |
SB 242084 是5-HT2C 选择性抑制剂,pKi 值9.0,是一种精神活性药物和研究化学品。 | |||
T37114 |
SB 242084 dihydrochloride
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SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.... |