Cat. No. | Product Name | Target | Signaling Pathways |
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T40341 |
SARS-CoV-2-IN-11
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SARS-CoV-2-IN-11 is a highly potent and non-toxic inhibitor of the 3C-like protease (3CLpro) of SARS-CoV-2, demonstrating IC50 and EC50 values of 0.17 nM and 1.45 nM, respectively. This compound targets the essential viral replication enzyme, 3CLpro, making it an attractive candidate for intervention strategies. SARS-CoV-2-IN-11 holds significant promise in the development of specific antivirals against SARS-CoV-2. | |||
T72313 |
SARS-CoV-2 3CLpro-IN-11
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SARS-CoV-2 3CLpro-IN-11(11d)为一种针对SARS-CoV-2 3CL蛋白酶的有效抑制剂,具备IC50值140 nM,并对SARS-CoV-1和MERS-CoV分别展现出IC50值240 nM与70 nM的抑制活性,显示出其广谱的抗病毒能力。 | |||
T60818 |
SARS-CoV-2-IN-15
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SARS-CoV-2-IN-15 (compound 11) 是一种氯硝柳胺类似物,其在人血浆和肝 S9 酶测定中比氯硝柳胺具有更高的稳定性。当口服给药时,它可以提高生物利用度和半衰期。SARS-CoV-2-IN-15 是SARS-CoV-2的有效抑制剂,IC50值为 0.49 μM。 | |||
T71191 |
Covidcil-19
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Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude. | |||
T76849 | Bamlanivimab | ||
Bamlanivimab (Anti-Human SARS-CoV-2) 是一种针对COVID-19的单克隆抗体(mAb),于2020年11月获得美国食品药品监督管理局(FDA)的紧急使用授权(EUA)。然而,由于SARS-CoV-2病毒耐药性变体的增多,该授权于2021年4月被撤销。 | |||
T38174 | Mpro inhibitor N3 hemihydrate | ||
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses... |