2
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38716 |
SAR247799
SAR247799,S1P1 agonist 3 |
||
SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 holds promise as a valuable tool for investigating endothelial protection, particularly in the context of type-2 diabetes and metabolic syndrome[4]. | |||
T70699 |
SAR296968
|
||
SAR296968 is a novel selective NCX inhibitor, improving cardiac function and restoring sympathovagal balance in heart failure. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KA... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... |