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Search Results for " resolvin d1 "

4

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...
T37168	Resolvin D1 methyl ester Resolvin D1 methyl ester
	Resolvin D1 is produced physiologically from the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase . It reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with an EC50 value of ~30 nM. RvD1 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracell...
T83661	17(R,S)-Benzo-Resolvin D1 17(R,S)-Benzo-RvD1,Benzo-RvD1
	17(R,S)-Benzo-resolvin D1 (benzo-RvD1) 是专门的分辨介质 (SPM) RvD1 的衍生物。在10和100 nM的浓度下，它能减少PDGF-BB诱导的人类血管平滑肌细胞 (VSMCs) 的细胞骨架变化，并抑制PDGF诱导的这些细胞的迁移。Benzo-RvD1 (10 nM) 抑制人脐静脉内皮细胞 (HUVECs) 中的p65核转位。它还提高了RAW 264.7对S. aureus和zymosan颗粒的吞噬作用。
T33613	NCGC00135472 NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472	Others	Others
	NCGC00135472 (DRV1 (GPR32) agonist C2A)是具有促分解功能的人Resolvin D1受体激动剂,可在β阻滞素和 cAMP 测定中激活人溶解蛋白 D1 受体 DRV1/GPR32 受体，EC50 分别为 0.37 uM 和 0.05 uM。NCGC00135472在过表达重组DRV1的细胞中引起快速阻抗变化，刺激血清处理的酶聚糖的吞噬作用。

化合物

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Resolvin D1 methyl ester

Cat.No: T37168

Synonym: Resolvin D1 methyl ester

17(R,S)-Benzo-Resolvin D1

Cat.No: T83661

Synonym: 17(R,S)-Benzo-RvD1,Benzo-RvD1

Cat.No: T33613

Synonym: NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。

天然产物

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

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