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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T36485 Becatecarin

Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.

化合物

Becatecarin
Cat.No: T36485
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T16726 Rebeccamycin

Topoisomerase DNA Damage/DNA Repair
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.

天然产物

Rebeccamycin
Cat.No: T16726
Synonym:
Target: Topoisomerase
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