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抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T8645 PF-06446846

Others Others
PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome,选择性地直接抑制 PCSK9 的翻译。
T14374 AZD2906

AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.
T37441 KMN-80

The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...

化合物

PF-06446846
Cat.No: T8645
Synonym:
Target: Others
AZD2906
Cat.No: T14374
Synonym:
Target:
KMN-80
Cat.No: T37441
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TL0008 Gigantol

Wnt/beta-catenin; Glucosidase Cytoskeletal Signaling; Metabolism; Stem Cells
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。

天然产物

Gigantol
Cat.No: TL0008
Synonym:
Target: Wnt/beta-catenin, Glucosidase
TargetMol Loading
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