Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12750 |
ROR agonist-1
|
Others | Others |
ROR agonist-1 is a potent and orally bioavailable the retinoic acid receptor-related orphan receptor C2 (RORC2) inverse agonist(inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5). | |||
T67943 |
RORγ inverse agonist 1
|
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RORγ inverse agonist 1具有抗炎活性,可用来治疗风湿和银屑病。 | |||
T39797 |
RORγ agonist 1
|
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RORγ agonist 1 is a highly potent and orally bioavailable compound that activates the RORγ receptor. Its efficacy is demonstrated by an EC50 value of 21 nM and it exhibits antitumor activity. | |||
T4050 |
GSK2981278
ROR gama modulator 1 |
ROR | Metabolism |
GSK2981278 (ROR gama modulator 1) 是 RORγ的选择性反向激动剂。它能够抑制 il17启动子的激活,并且干扰 RORγ-DNA 结合。 |