Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13320L |
VU591
|
Potassium Channel | Membrane transporter/Ion channel |
VU591 是选择性的肾外髓钾通道抑制剂,IC50为 0.24 μM。 | |||
T13320 |
VU591 hydrochloride
|
Potassium Channel | Membrane transporter/Ion channel |
VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂,IC50为 0.24 μM。 | |||
T70634 | Psycholeine | ||
Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion. | |||
T23516 |
VU590
|
Potassium Channel | Membrane transporter/Ion channel |
VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1,可调节子宫肌层收缩力和黑皮质素信号传导。 | |||
T24623 |
PF-06807656
PF 06807656 |
||
PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM). | |||
T12066 |
MK-7145
|
Others | Others |
MK-7145 is an inhibitor of ROMK(IC50 of 0.045 μM). | |||
T70636 |
XAN35021
|
||
XAN35021, also known as ROMK inhibitor 25, or ROMK-IN-25, is a potent and selective ROMK inhibitor with improved pharmacokinetic properties. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming). | |||
T62760 |
ROMK-IN-32
|
||
ROMK-IN-32 是一种肾外髓质钾通道 (ROMK) 抑制剂 (IC50: 35 nM),也能够抑制 hERG (IC50: 22 μM)。 | |||
T62544 |
MK-8153
|
||
MK-8153 是一种选择性的、有效的、口服具有活力的肾外髓质钾通道 (ROMK) 抑制剂,作用于 ROMK EP (IC50: 5 μM) 和 hERG EP (IC50: 34 μM)。MK-8153 能够用作利尿剂。 |