Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T69360 |
RO3244794
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
RO3244794是一种具有选择性的前列环素 (IP)受体拮抗剂,可用于研究肝脏损伤。 | |||
T38171 | Ro 1138452 hydrochloride | ||
Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable. Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID:15013022 |Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel ... |