首页工具

搜索结果

Search Results for " rn9893 (hydrochloride) "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T28548	RN9893 RN9893 Hydrochloride,RN 9893 HCl,RN-9893 HCl,RN-9893,RN-9893 Hydrochloride,RN 9893 Hydrochloride	TRP/TRPV Channel	Membrane transporter/Ion channel
	RN9893 是一种具有选择性和高效性的 TRPV4 受体拮抗剂，对小鼠、人类和大鼠的 TRPV4 受体的 IC50 值分别为 320、420 和 660 nM。
T37321	RN-9893 (hydrochloride)
	RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors).1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively). RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays). \|1. Wei, Z.L., Nguyen, M.T., O'Mahony, D.J., et al. Identification of orally-bioavailable antago...