Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8222 |
Selpercatinib
LOXO-292 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
Selpercatinib (LOXO-292) 是 RET 激酶抑制剂,抑制 RET (WT)、RET (V804M) 、RET (G810R)的 IC50分别为 14.0 nM、24.1 nM、530.7 nM,具有抗肿瘤活性。 | |||
T16735 |
RET-IN-1
|
Others | Others |
RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively). | |||
T63468 |
RET-IN-14
|
||
RET-IN-14 是 RET 的有效抑制剂,能够作用于 RET (WT) (IC50<0.51 nM)、RET (G810R) (IC50: 9.3 nM)、RET (V804M) (IC50: 1.3 nM)、BTK (C481S) (IC50: 9.2 nM) 和 BTK (C481S) (IC50: 15 nM)。RET-IN-14 表现出潜力进行肿瘤的研究。 |