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Search Results for " q-10 "

3

抑制剂 & 化合物

1

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36114	Coenzyme Q2
	Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. For...
T83775	STING Agonist 12L Stimulator of Interferon Genes Agonist 12L
	STING激动剂12L是一种刺激干扰素基因(STING)的激动剂。它与野生型STING结合(IC50 = 1.15 µM)，以及STING的R232、AQ和Q变体(IC50分别为1.06、0.61和1.12 µM)，并在THP-1和RAW 264.7细胞中诱导报告基因表达(EC50分别为0.38和12.94 µM)。STING激动剂12L (5 µM)在THP-1细胞中诱导IFNB1、CXCL10和IL6 mRNA的表达。在体内，STING激动剂12L (10 mg/kg)提高了血浆IFN-β水平，并且在B16/F10小鼠黑色素瘤模型中减少了肿瘤体积和肺转移灶的数量。
T36461	CAY10748 CAY10748
	CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β an...

化合物

Cat.No: T36114

STING Agonist 12L

Cat.No: T83775

Synonym: Stimulator of Interferon Genes Agonist 12L

Cat.No: T36461

Synonym: CAY10748

Cat. No.	Product Name	Target	Signaling Pathways
T2796	Coenzyme Q10 Ubiquinone-10,辅酶Q10,CoQ10	Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物，在线粒体呼吸链中充当电子载体。

天然产物

Cat.No: T2796

Synonym: Ubiquinone-10,辅酶Q10,CoQ10

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01186	Argonaute-2 Protein, Human, Recombinant (His) EIF2C2,argonaute RISC catalytic component 2,Argonaute 2,...	Human	Baculovirus Insect Cells
	Argonaute-2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 99 kDa and the accession number is Q9UKV8.
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor necrosis factor re...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated TRAMP,tumor necrosis factor receptor superfamily, member 25,...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-00961	ADAM15 Protein, Human, Recombinant (His) MDC15,ADAM metallopeptidase domain 15	Human	HEK293 Cells
	ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...

重组蛋白

Argonaute-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01186

Species: Human

Expression System: Baculovirus Insect Cells

DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01751

Species: Human

Expression System: HEK293 Cells

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05760

Species: Human

Expression System: HEK293 Cells

ADAM15 Protein, Human, Recombinant (His)

Cat.No: TMPY-00961

Species: Human

Expression System: HEK293 Cells

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

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