Cat. No. | Product Name | Target | Signaling Pathways |
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T37919 |
Prostaglandin F1α
PGF1α,Prostaglandin F1α |
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Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3] | |||
T36162 |
8-iso Prostaglandin F1α
8-iso Prostaglandin F1α |
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8-iso PGF1α is an isoprostane that was first identified in human semen. It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1α is present along with its 19-hydroxy congener at 5-10 μg/ml of seminal plasma. | |||
T37990 |
15-keto Prostaglandin F1α
15-keto Prostaglandin F1α |
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15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins. | |||
T36771 |
11-deoxy Prostaglandin F1α
11-deoxy Prostaglandin F1α |
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11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs. | |||
T36148 |
13,14-dihydro-15-keto Prostaglandin F1α
13,14-dihydro-15-keto Prostaglandin F1α |
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13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α. | |||
T36724 |
6,15-diketo-13,14-dihydro Prostaglandin F1α
6,15-diketo-13,14-dihydro Prostaglandin F1α |
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6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells. | |||
T83662 |
2,3-dinor-8-iso Prostaglandin F1α
2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP |
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2,3-dinor-8-iso Prostaglandin F1α(2,3-dinor-8-iso PGF1α)是一种异前列腺素和花生四烯酸的活性代谢物,也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩(EC50s分别为12.8和18.5 nM),但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时,它能增加孤立的猪大脑切片中的血栓素B2(TXB2)水平,这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体(nAChR)拮抗剂α-conotoxin来逆转。 | |||
T36772 |
11-deoxy Prostaglandin F1β
11-deoxy Prostaglandin F1β |
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11-deoxy PGF1β is a synthetic analog of PGF1β. In contrast to PGF2α and PGF1α, 11-deoxy PGF1β exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 μg/kg. | |||
T36163 |
8-iso Prostaglandin F1β
8-iso Prostaglandin F1β |
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8-iso PGF1β is a potential autoxidation product of DGLA. There are no published reports on its isolation from any biological source or on its biological activity. | |||
T71212 |
Lornoxicam-d4
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Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e... |