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Search Results for " pipendoxifene hydrochloride "

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Cat. No.	Product Name	Target	Signaling Pathways
T12482	Pipendoxifene hydrochloride	Estrogen Receptor/ERR	Endocrinology/Hormones
	Pipendoxifene hydrochloride 是雌激素受体的选择性调节剂。
T70013	Pipendoxifene
	Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an imp...