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25

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2381	F-Chemotactic peptide-fluorescein N-Formyl-nle-leu-phe-nle-tyr-lys-fluorescein,Fnlpntl-fluorescein
	F-Chemotactic peptide-fluorescein is a fluorescent label.
T81511	Peptide F, bovine
	Peptide F, bovine，是源自牛大脑和肾上腺髓质的前脑啡肽F，与脑啡能系统的疼痛传导过程相关。
TP2476	Tnrnflrfamide Thr-asn-arg-asn-phe-leu-arg-phe-NH2,Peptide F(1), lobster,F1 Peptide, lobster,Lobster peptide F1
	Tnrnflrfamide is a SCP (small cardioactive peptide)-like peptide found in lobster neurons; exhibits FMRFamide-like immunoreactivity.
T75412	Peptide-N-Glycosidase F (PNGaseF)
	Peptide-N-Glycosidase F (PNGaseF) 是一种天冬酰胺酰胺酶。Peptide-N-Glycosidase F 催化来自糖蛋白的高甘露糖、杂合和复杂寡糖的内层 GlcNAc 和天冬酰胺残基之间的 N-连接寡糖裂解。Peptide-N-Glycosidase F 可用于糖蛋白的结构和功能研究。
T80851	VSTx-3 Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3是KV通道阻断剂，同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言，其对hNaV1.3通道的IC50为0.19 μM，对hNaV1.7通道的IC50为0.43 μM，对hNaV1.8通道的IC50为0.77 μM。
T81514	Peptide 5f
	Peptide 5f 是一种源自大黄蜂毒液的抗菌肽，对细菌和真菌展现出显著的抗菌活性，同时对人类血红细胞的溶血活性极低。
TP1926	WRW4 TFA(878557-55-2 free base) WRW4	Others	Others
	WRW4 TFA (878557-55-2 free base) 是一种特异性的甲酰肽受体样 1 (FPRL1) 拮抗剂，抑制 WKYMVm 与 FPRL1 的结合，IC50 为 0.23 μM。 WRW4 通过 FPRL1 激动剂 MMK-1、淀粉样蛋白 beta42 (Abeta42) 肽和 F 肽特异性抑制细胞内钙的增加。
T69718	Bacitracin F
	Bacitracin F is a major Bacitracin analog -- a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI).
T24796	SK&F 107260 Skf107260,Skf-107260,Skf 107260
	SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb/IIIa antagonist and a vitronectin antagonist.
T82290	Glycocin F
	Glycocin F为一种具有针对乳杆菌活性的抗菌肽。
T39793	Fmoc-Tyr(3-F,tBu)-OH
	Fmoc-Tyr(3-F, tBu)-OH is a cyclic peptide compound possessing high membrane permeability and exhibiting specific binding affinity towards a target molecule.
T25401	F-991 Ala-his-trp-ser-gly-his-cys-cys-leu,F 991,F991
	F-991 is a peptide inhibitor that has shown remarkable biological activity in a number of animal models of allergic diseases, and promise for the potential treatment of allergic diseases in humans.
T75814	WRW4 TFA
	WRW4 TFA 是FPRL1（甲酰肽受体样1）的特异性拮抗剂，对WKYMVm与FPRL1的结合具有0.23 μM的IC50抑制作用。此外，WRW4 TFA能够阻止FPRL1激动剂MMK-1、淀粉样β42 (Abeta42) 肽和F肽导致的细胞内钙水平上升。
T78328	Efbemalenograstim alfa F 627,Bineuta,Benegrastim
	Efbemalenograstim alfa（F 627）为重组长效二聚体G-CSF，融合了两个人源G-CSF与人免疫球蛋白G2（hIgG2）-Fc片段，并能有效促进白细胞生成。
T82423	F(N-Me)GA(N-Me)IL
	F(N-Me)GA(N-Me)IL 是一种双N-甲基化衍生的生物活性肽，缺乏β-折叠结构且不具备淀粉样蛋白形成性及细胞毒性。与天然序列相互作用时，该衍生物能有效抑制淀粉样蛋白的形成。
T77894	Val-Cit-PAB-MMAF sodium
	Val-Cit-PAB-MMAFsodium为抗体药物偶联物（ADC）的活性组分，其结构由ADC连接子（肽类连接子Val-Cit-PAB）与高效微管蛋白聚合抑制剂MMAF通过偶联形成。
T81176	Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2
	Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 是一种具备生物活性的肽。研究凝血酶受体束缚配体 SFLLRNP 的结构活性表明，Phe-2-苯基在受体识别过程中具有关键作用。研究还发现，将 Phe-2 替换为对氟苯丙氨酸 [(pF)Phe]，可以提升其生物活性。
TP1322	Bacterial Sortase Substrate III, Abz/DNP (TFA)
	Bacterial Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the f
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
TP1816	Urotensin II, mouse
	Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。
T37483	Difelikefalin (trifluoroacetate salt)
	Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50= 0.048 nM). Difelikefalin is selective for KOR over the μ-opioid receptor (MOR; EC50= >1 μM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 m...
T35597	Neuromedin U-23 (rat) (trifluoroacetate salt)
	Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.1It is an agonist of neuromedin-U receptor 1 (NMUR1; EC50= 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50= ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor).2,3NMU-23 (1 μM) induces contractions in isolated rat colon smooth muscle strips.4It decreases body ...

化合物

F-Chemotactic peptide-fluorescein

Cat.No: TP2381

Synonym: N-Formyl-nle-leu-phe-nle-tyr-lys-fluorescein,Fnlpntl-fluorescein

Peptide F, bovine

Cat.No: T81511

Cat.No: TP2476

Synonym: Thr-asn-arg-asn-phe-leu-arg-phe-NH2,Peptide F(1), lobster,F1 Peptide, lobster,Lobster peptide F1

Peptide-N-Glycosidase F (PNGaseF)

Cat.No: T75412

Cat.No: T80851

Synonym: Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F

Cat.No: T81514

WRW4 TFA(878557-55-2 free base)

Cat.No: TP1926

Synonym: WRW4

Target: Others

Cat.No: T69718

Cat.No: T24796

Synonym: Skf107260,Skf-107260,Skf 107260

Cat.No: T82290

Fmoc-Tyr(3-F,tBu)-OH

Cat.No: T39793

Cat.No: T25401

Synonym: Ala-his-trp-ser-gly-his-cys-cys-leu,F 991,F991

Cat.No: T75814

Efbemalenograstim alfa

Cat.No: T78328

Synonym: F 627,Bineuta,Benegrastim

F(N-Me)GA(N-Me)IL

Cat.No: T82423

Val-Cit-PAB-MMAF sodium

Cat.No: T77894

Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2

Cat.No: T81176

Bacterial Sortase Substrate III, Abz/DNP (TFA)

Cat.No: TP1322

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Urotensin II, mouse

Cat.No: TP1816

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Difelikefalin (trifluoroacetate salt)

Cat.No: T37483

Neuromedin U-23 (rat) (trifluoroacetate salt)

Cat.No: T35597

Cat. No.	Product Name	Target	Signaling Pathways
T11712	Jasplakinolide Jaspamide,NSC-613009	Microtubule Associated; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。
T13940	Tubulysin F	Others	Others
	Tubulysin F is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin F is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce

天然产物

Cat.No: T11712

Synonym: Jaspamide,NSC-613009

Target: Microtubule Associated, Antifungal

Cat.No: T13940

Target: Others

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