Cat. No. | Product Name | Target | Signaling Pathways |
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T71338 |
Patidegib HCl
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Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligan... | |||
T16843 |
Saridegib
IPI-926,Patidegib |
Others | Others |
Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway. | |||
T71336 |
CASP3 Activator 1541B
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CASP3 Activator 1541B is an activator of the proenzyme forms of caspase-3, and is an inducer of cell death. |