Cat. No. | Product Name | Target | Signaling Pathways |
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T76538 |
Pancreatic polypeptide
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Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽,具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。 | |||
TP1137L |
Pancreatic Polypeptide (human) acetate
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Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽,可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。 | |||
TP1044L |
Pancreatic Polypeptide, rat acetate
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Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Pancreatic Polypeptide, rat acetate 是 NPY 受体的激动剂,对 NPYR4 具有高亲和力。 | |||
TP1137 |
Pancreatic Polypeptide, human
Human pancreatic polypeptide |
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Endogenous high affinity agonist for human NPY Y4 receptor (Ki = 0.056 nM). Believed to play an important role in the function of the gastrointestinal tract. | |||
TP1731 |
Pancreatic Polypeptide, bovine
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Agonist at Y4 neuropeptide Y receptors. | |||
TP1044 |
Pancreatic Polypeptide, rat
Rat pancreatic polypeptide |
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Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cel | |||
TP1125 |
Insulin(cattle)
牛胰岛素,Insulin from bovine pancreas,胰岛素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Insulin cattle (Insulin from bovine pancreas) 是一种在胰腺 β 细胞中产生的两链多肽激素,在很多哺乳动物细胞培养体系中用作生长因子。 | |||
T40495 |
Elastase from porcine pancreas
弹性蛋白酶,EC 3.2.1.35 |
Others | Others |
Elastase from porcine pancreas 由 240 个氨基酸残基组成,是一种丝氨酸蛋白酶,可以水解蛋白质和多肽。它可诱发仓鼠气肿。 | |||
T37528 |
tBPC
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Positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R. Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID:28795803 | |||
T76028 |
Amylin (IAPP), feline TFA
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Amylin (IAPP), feline TFA,一种来自猫科动物、含37个氨基酸的多肽,为胰岛β细胞的主要分泌物之一。作为调节肽,它能够抑制胰岛素和胰高血糖素的分泌。 | |||
T75787 |
Amylin, amide, human TFA
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Amylin, amide, human TFA 是一种含有37个氨基酸的胰腺多肽,与胰岛素共同分泌,对代谢和维持葡萄糖稳态具有重要作用。该化合物能够抑制胰高血糖素的分泌,延缓胃排空速度,同时作为增加饱腹感的因子。 | |||
T82316 |
GIP, rat TFA
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GIP, rat TFA 是一种源自大鼠的生物活性肽。GIP(Glucose-dependent Insulinotropic Polypeptide,又名 Gastric Inhibitory Polypeptide)是由十二指肠与空肠中的K细胞在摄食后释放的一种含42个氨基酸的多肽。作为肠促胰岛素激素肽家族的一部分,GIP和GLP(Glucagon-Like Peptide)共同调控胰岛β细胞的胰岛素分泌,并可能促进β细胞扩增及存活。此外,近期研究显示GIP参与调节脂质平衡,并可能在肥胖的病理生理中扮演角色。 | |||
T82317 |
GIP, rat
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GIP, rat 是一种由十二指肠和空肠 K 细胞在食物摄入后分泌的具有生物活性的肽,由 42 个氨基酸组成。作为肠促胰岛素激素肽家族的一员,GIP 与另一激素 GLP 共同负责刺激胰岛 β 细胞分泌胰岛素,并促进 β 细胞的增殖与存活。近期研究显示GIP 在调控脂质平衡及肥胖发病机制中发挥重要作用。 | |||
T36864 |
GRP (human) (trifluoroacetate salt)
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Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM. In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats. It dose-depend... |