Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8879 |
MR837
ZINC30303842,NSD2-PWWP1 antagonist 3f |
Others; Histone Methyltransferase | Chromatin/Epigenetic; Others |
MR837 (NSD2-PWWP1 antagonist 3f) 是可与人核受体结合 SET 结构域蛋白(PWWP 结构域) 结合的NSD2-PWWP1抑制剂。 | |||
T9584 |
UNC6934
|
Others; Histone Methyltransferase | Chromatin/Epigenetic; Others |
UNC6934 是一种针对 NSD2 的 N 端 PWWP (PWWP1) 结构域的化学探针,可定位核仁。 | |||
T10538 |
BI-9321
|
Others | Others |
BI-9321 is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. | |||
T10538L |
BI-9321 trihydrochloride
|
Others | Others |
BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. | |||
T62705 |
NSD2-IN-1
|
||
NSD2-IN-1 (compound 38) 是一种有效的、高选择性的 NSD2-PWWP1(核受体结合 SET 结构域 2-PWWP1) 抑制剂,IC50为 0.11 μM。NSD2-IN-1 可以与 NSD2-PWWP1 结合,进而影响受 NSD2 调控的基因表达。NSD2-IN-1 可以诱导细胞凋亡 (apoptosis) 和细胞周期阻滞。 | |||
T79616 |
UNC7096
|
Histone Methyltransferase | Chromatin/Epigenetic |
UNC7096为一种选择性NSD2-PWWP1抑制剂,其Kd为46 nM,拥有潜在治疗NSD2相关疾病的能力。 | |||
T79615 |
MS9715
|
Histone Methyltransferase | Chromatin/Epigenetic |
MS9715是一高效的选择性NSD3PROTAC,通过E3连结酶VHL配体与NSD3的PWWP1结构域相结合而由BI-9321设计。该化合物对于NSD3依赖性癌症治疗的研究具有潜在应用价值。 |