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3

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T37581	SCIO 469 hydrochloride
	Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells. Hideshima et al (2004) p38 MAPK inhibition enhances P...
T12871	Talmapimod 他匹莫德,SCIO-469	p38 MAPK	MAPK
	Talmapimod (SCIO-469) 是选择性的，具有口服活性的，ATP 竞争性的 p38α抑制剂，对 p38α和 p38β的 IC50 值分别是 9 nM 和90 nM。Talmapimod 在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。
T12871L	Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK	MAPK
	Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.

化合物

SCIO 469 hydrochloride

Cat.No: T37581

Cat.No: T12871

Synonym: 他匹莫德,SCIO-469

Target: p38 MAPK

Talmapimod hydrochloride

Cat.No: T12871L

Synonym: SCIO-469 hydrochloride

Target: p38 MAPK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03848	Protein S/PROS1 Protein, Human, Recombinant (His) PS21,PSA,PS23,PS	Human	HEK293 Cells
	Protein S/PROS1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.1 kDa and the accession number is P07225.
TMPY-02412	ENO1 Protein, Human, Recombinant (His) PPH,NNE,enolase 1, (alpha),ENO1L1,HEL-S-17,MPB1,enolase 1, (...	Human	E. coli
	ENO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 49.3 kDa and the accession number is P06733-1.
TMPY-02258	Kallikrein 3/KLK3 Protein, Human, Recombinant (His) APS,KLK2A1,PSA,kallikrein related peptidas...	Human	HEK293 Cells
	KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that is synthesized in the epithelial cells of the prostate gland and is present in seminal plasma. KLK3, also known as Prostate Specific Antigen (PSA), kallikrein-related peptidase 3, Gamma-seminoprotein, is a secreted protein of the glandular kallikrein subfamily of serine proteases....
TMPY-06315	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His) protein S (alpha),protein S (α)	Cynomolgus	HEK293 Cells
	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.18 kDa and the accession number is A0A7N9CCZ7.

重组蛋白

Protein S/PROS1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03848

Species: Human

Expression System: HEK293 Cells

ENO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02412

Species: Human

Expression System: E. coli

Kallikrein 3/KLK3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02258

Species: Human

Expression System: HEK293 Cells

Protein S/PROS1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06315

Species: Cynomolgus

Expression System: HEK293 Cells

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