Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13847 |
PROTAC SGK3 degrader-1
SGK3-PROTAC1 |
SGK; PROTACs | Metabolism; PROTAC |
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种靶向 SGK3 且与 VH032 VHL 结合配体的 PROTAC 偶联物,可诱导内源性 SGK3 降解。PROTAC SGK3 degrader-1 可抑制GDC0941诱导的癌细胞增殖。 | |||
T18513 |
OTs-C6-OBn
|
Others; PROTAC Linker | Others; PROTAC |
OTs-C6-OBn 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC SGK3 degrader-1 的合成。 | |||
T18533 |
PEG3-C4-OBn
|
Others | Others |
PEG3-C4-OBn, a polyethylene glycol (PEG)-based PROTAC linker, is utilized in crafting the PROTAC SGK3 degrader-1, a potent SKG3 degrader leveraging PROTAC technology [1][2]. | |||
T14158 |
Ald-CH2-PEG3-CH2-Boc
|
Others | Others |
Ald-CH2-PEG3-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, is utilized for the synthesis of SGK3 kinase PROTAC degrader[1]. | |||
T17646 |
Boc-C1-PEG3-C4-OBn
|
Others | Others |
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PEG-based PROTAC linker employed in the synthesis of various PROTACs, including PROTAC SGK3 degrader-1. PROTACs are composed of two distinct ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, while the other specifically interacts with the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs can selectively degrade target proteins[1]. |