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Cat. No. Product Name Target Signaling Pathways
T13847 PROTAC SGK3 degrader-1

SGK3-PROTAC1

SGK; PROTACs Metabolism; PROTAC
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种靶向 SGK3 且与 VH032 VHL 结合配体的 PROTAC 偶联物,可诱导内源性 SGK3 降解。PROTAC SGK3 degrader-1 可抑制GDC0941诱导的癌细胞增殖。
T18513 OTs-C6-OBn

Others; PROTAC Linker Others; PROTAC
OTs-C6-OBn 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC SGK3 degrader-1 的合成。
T18533 PEG3-C4-OBn

Others Others
PEG3-C4-OBn, a polyethylene glycol (PEG)-based PROTAC linker, is utilized in crafting the PROTAC SGK3 degrader-1, a potent SKG3 degrader leveraging PROTAC technology [1][2].
T14158 Ald-CH2-PEG3-CH2-Boc

Others Others
Ald-CH2-PEG3-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, is utilized for the synthesis of SGK3 kinase PROTAC degrader[1].
T17646 Boc-C1-PEG3-C4-OBn

Others Others
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PEG-based PROTAC linker employed in the synthesis of various PROTACs, including PROTAC SGK3 degrader-1. PROTACs are composed of two distinct ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, while the other specifically interacts with the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs can selectively degrade target proteins[1].

化合物

PROTAC SGK3 degrader-1
Cat.No: T13847
Synonym: SGK3-PROTAC1
Target: SGK, PROTACs
OTs-C6-OBn
Cat.No: T18513
Synonym:
Target: Others, PROTAC Linker
PEG3-C4-OBn
Cat.No: T18533
Synonym:
Target: Others
Ald-CH2-PEG3-CH2-Boc
Cat.No: T14158
Synonym:
Target: Others
Boc-C1-PEG3-C4-OBn
Cat.No: T17646
Synonym:
Target: Others
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