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Cat. No. Product Name Target Signaling Pathways
T40112 PROTAC PD-1/PD-L1 degrader-1

PROTAC PD-1/PD-L1 degrader-1

PROTACs PROTAC
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.

化合物

PROTAC PD-1/PD-L1 degrader-1
Cat.No: T40112
Synonym: PROTAC PD-1/PD-L1 degrader-1
Target: PROTACs
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