Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74138 |
PROTAC Bcl-xL degrader-2
|
PROTACs | PROTAC |
PROTACBcl-xLdegrader-2 是一种基于von Hippel-Lindau 配体的Bcl-xL(Bcl-2家族成员) 降解剂,IC50为 0.6 nM。 | |||
T39910 |
Desmorpholinyl Navitoclax-NH-Me
Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me |
BCL | Apoptosis |
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. | |||
T40135 |
PZ703b
|
PROTACs | PROTAC |
PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition. | |||
T73957 | PROTAC Bcl-xL degrader-1 | ||
PROTACBcl-xL degrader-1是一种针对Bcl-xL(Bcl-2家族成员)的PROTAC,具备配体结合基团、linker以及IAPE3连接酶结合基团。这种化合物是一个有效的Bcl-xL降解剂,对人血小板和MyLa 1929细胞显示出明显的毒性,其IC50值分别为62 nM和8.5 μM。 | |||
T39909 |
XZ739
XZ739 |
PROTACs | PROTAC |
XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-mediated apoptosis. | |||
T73826 |
PZ703b hydrochloride
|
PROTACs | PROTAC |
PZ703b hydrochloride 是一种Bcl-xlPROTAC 降解剂,可以诱导细胞凋亡 (apoptosis),抑制癌细胞增殖。PZ703b hydrochloride 可用于膀胱癌的研究。 |