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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T60770 PqsR/LasR-IN-3

PqsR/LasR-IN-3 (Compound 7a) 抑制 hERG,IC50值为 109.01 μM。它也是铜绿假单胞菌中PqsR 和LasR 系统的有效抑制剂。
T61353 PqsR-IN-2

PqsR-IN-2 (Compound 19) is a highly potent inhibitor of PqsR, the transcriptional regulator responsible for quorum sensing in Pseudomonas aeruginosa. It effectively suppresses pyocyanin production without causing significant cytotoxicity, making it a promising compound for therapeutic applications [1].
T62015 PqsR/LasR-IN-1

PqsR/LasR-IN-1 (Compound 2a) 是铜绿假单胞菌中LasR 和PqsR 系统的有效抑制剂。PqsR/LasR-IN-1 也是 hERG 的抑制剂,IC50为 6.77 μM。
T61169 PqsR-IN-1

PqsR-IN-1 (Compound 18) is a potent inhibitor of PqsR, which is a transcriptional regulator involved in the quorum sensing mechanism of Pseudomonas aeruginosa. This compound effectively reduces the production of pyocyanin and exhibits minimal cytotoxicity [1].

化合物

PqsR/LasR-IN-3
Cat.No: T60770
Synonym:
Target:
PqsR-IN-2
Cat.No: T61353
Synonym:
Target:
PqsR/LasR-IN-1
Cat.No: T62015
Synonym:
Target:
PqsR-IN-1
Cat.No: T61169
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T38373 2-heptyl-3-hydroxy-4(1H)-Quinolone

2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Others Others
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。 它增加了铜绿假单胞菌中lasB 基因的表达,增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌,以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时,它还会降低铜绿假单胞菌生长介质中的铁含量,并在硫酸铁溶液中充当一种铁螯合剂。

天然产物

2-heptyl-3-hydroxy-4(1H)-Quinolone
Cat.No: T38373
Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal
Target: Others
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