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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9753 |
LEI110
|
Phospholipase | Metabolism |
LEI110 是一种有效的 Phospholipase A2, group XVI (PLA2G16) 抑制剂,Ki 值为 20 nM。 LEI110 是 HRASLS 硫醇水解酶家族(即 PLA2G16、HRASLS2、RARRES3 和 iNAT)的选择性泛抑制剂。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01010 |
PLA2G16 Protein, Human, Recombinant (His)
Renal Carcinoma Antigen NY-REN-65,HRAS-Like Suppressor 1,HRS... |
Human | E. coli |
Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids through a G-protein coupled pathway involving prostaglandin and EP3. It has also been reported to play a crucial role in the development of obesity in mouse models. |