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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T70352	PH11
	PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL...
T38632	Ald-Ph-amido-PEG11-NH-Boc Ald-Ph-amido-PEG11-NH-Boc
	Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable 11-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs).
T38733	Ald-Ph-amido-PEG11-C2-NH2 Ald-Ph-amido-PEG11-C2-NH2
	Ald-Ph-amido-PEG11-C2-NH2 is an 11-unit polyethylene glycol (PEG) linker that is non-cleavable. It is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs).
T70351	VS-II-173
	VS-II-173 is a novel potent Pim1 and Pim3 inhibitor, selectively inducing AML cell death.
T37049	monoMICAAc
	monoMICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of monoMICAAc increases. It displays excitation/emission maxima of 425/491, 437/515, and 472/554 nm in hexane, dioxane, and water, respectively. The absorption maximum of monoMICAAc decreases with increasing pH. It displays absorbance/emission maxima of 475/553 and 446/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increa...
T36843	ICAAc
	ICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decre...
T37832	CAY10761 CAY10761
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...

化合物

Ald-Ph-amido-PEG11-NH-Boc

Cat.No: T38632

Synonym: Ald-Ph-amido-PEG11-NH-Boc

Target:

Ald-Ph-amido-PEG11-C2-NH2

Cat.No: T38733

Synonym: Ald-Ph-amido-PEG11-C2-NH2

Synonym: CAY10761

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T5S1569	AKBA 乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid	Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others
	AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分，是新颖的 Nrf2 的活化剂。