Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16492 |
PF-06459988
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PF-06459988 是一种新型的的、有效的、具有口服活性的、不可逆的和选择性的表皮生长因子受体( EGFR) 突变体抑制剂。PF-06459988 对含 T790M 的 EGFRs 双突变体具有高效性和高亲和力,对 WT EGFR 具有极小的活性。PF-06459988 使治疗癌症的候选药物。 | |||
T39299 |
(3S,4S)-PF-06459988
|
||
(3S, 4S)-PF-06459988 is the less active S enantiomer of PF-06459988, which is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 exhibits excellent selectivity against EGFR wild-type due to its minimally reactive electrophile, which reduces the likelihood of off-target labeling. |