2
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11141 |
E64FC26
|
Others | Others |
E64FC26 是一种有效的蛋白质二硫键异构酶 (PDI) 家族泛抑制剂,具有抗肿瘤活性,抑制 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6,可用于研究多发性骨髓瘤和胰腺癌。 | |||
T39812 |
(E/Z)-E64FC26
(E/Z)-E64FC26 |
||
(E/Z)-E64FC26 is a mixture complex comprising E-E64FC26 and Z-E64FC26. E-E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50 values of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Furthermore, E64FC26 demonstrates anti-myeloma activity. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01124 |
PDIA6 Protein, Human, Recombinant (His)
Thioredoxin Domain-Containing Protein 7,P5,ERP5,TXNDC7,Prote... |
Human | Human Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA... |