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Search Results for " pbp "

17

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1948	PBP10 PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exh
T33894	PBP2 PBP-2,PBP 2
	PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells.
T33893	PBP1 PBP-1,PBP 1
	PBP1 is a selective inducer of i-motif structures from the unstructured single-stranded DNA conformations which upregulates BCL-2 gene expression in cancer cells.
TP1948L	PBP 10 acetate(794466-43-6 Free base)
	PBP 10 acetate(794466-43-6 Free base) 是一种选择性甲酰肽受体 2 (FPR2) 拮抗剂。 PBP 10 acetate 选择性抑制 FPR2 介导的 NADPH 氧化酶活性，但对中性粒细胞中的 FPR1 信号传导没有影响。 PBP 10 acetate 在体外表现出 PIP2 结合活性并阻断细胞运动。 PBP 10 acetate 通过抑制病毒诱导的 ERK 激活而表现出针对流感病毒的抗病毒活性。
T78306	Ulenistamab PBP1510
	Ulenistamab (PBP1510)为首创人源化IgG1单克隆抗体，专一靶向胰腺癌上调因子(PAUF)，适用于胰腺癌(PC)的研究。
T1070	Cefmetazole sodium 头孢美唑钠,Sodium cefmetazole	Antibacterial; Antibiotic	Microbiology/Virology
	Cefmetazole sodium (Sodium cefmetazole) 是具有广谱抗菌活性的半合成头孢霉素抗生素。它通过与青霉素结合蛋白结合，阻止肽聚糖的交联，导致细胞壁完整性的丧失。它可研究妇科、腹腔内、尿道、呼吸道和皮肤和软组织感染。
T81279	RhB-PBP10 TFA
	RhB-PBP10 TFA，一种Rhodamine B 标记的PBP10 TFA （FPR2 拮抗剂），有效选择性地抑制FPRL1 在中性粒细胞中诱导的颗粒动员以及氧自由基的分泌。
T75811	PBP10 TFA
	PBP10是一种细胞通透性和选择性的gelsolin衍生的肽抑制剂，针对甲酰基肽受体2(FPR2)具有较高选择性，相较于FPR1更为优选。该化合物为N端偶联罗丹明的10个氨基酸肽，对革兰氏阳性及革兰氏阴性菌均展现出杀菌活性，同时能够抑制微生物诱导的炎症反应。
T22513	4-PPBP maleate	Sigma receptor; NMDAR	GPCR/G Protein; Neuroscience
	4-PPBP maleate 是一种有效的 σ1 受体（配体）激动剂。4-PPBP maleate 在Xenopus oocytes 表达的情况下可被认为是一种具有选择性、非竞争性的 NR1a/2B NMDA 受体拮抗剂。4-PPBP maleate 具有神经保护特性。
T1005L	Amoxicillin trihydrate Amoxycillin trihydrate,Amoxil trihydrate,Amoxipen trihydrate,阿莫西林三水物,Moxaline trihydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Amoxicillin trihydrate (Moxaline trihydrate) 是一种中谱β内酰胺抗菌素。
T0953	Cefazolin sodium Ancef,头孢唑啉钠,头孢唑林钠,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Cefazolin sodium (cephazolin sodium) salt 是一种头孢类抗生素, 可研究多种细菌感染。
T1122	Cephalothin sodium 头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin	Antibacterial; Antibiotic	Microbiology/Virology
	Cephalothin sodium (Cefalotin) 是一种头孢类抗生素, 具有广泛的抗菌活性，抑制革兰氏阳性和阴性菌。
T12166	Nacubactam OP0595 free acid,那库巴坦	Antibacterial	Microbiology/Virology
	Nacubactam (OP0595 free acid) 是一种非 β-内酰胺-β-内酰胺酶抑制剂，对 A 类和 C 类 β-内酰胺酶具有活性。它作为青霉素结合蛋白 2 活性抗菌剂，并赋予 β-内酰胺酶非依赖性增强作用以靶向其他 PBP。
T75288	Tebipenem pivoxil hydrochloride
	Tebipenem pivoxil (L084) hydrochloride 是具口服活性、对多种致病菌有效的抗生素。通过结合青霉素结合蛋白 (PBP) 抑制细胞壁合成。
T81157	SIGSLAK
	SIGSLAK 拥有与大肠杆菌青霉素结合蛋白 1b (PBP1b) 活性位点相对应的结构特征。
T61204	FPI-1465
	FPI-1465 是丝氨酸-β-内酰胺酶和青霉素结合蛋白 (PBP) 的双重抑制剂。FPI-1465 抑制PBP2，IC50为 1.0 μg/mL。FPI-1465 作用于 β-内酰胺酶 CTX-M-15 和 OXA-48，Kd 分别为 0.011 和 5.3 μM。
T73859	Methicillin sodium hydrate
	Methcillin sodium hydrate 是一种窄谱 β-内酰胺类抗生素，通过抑制青霉素结合蛋白 (penicillin-binding proteins,PBP) 发挥作用。Methcillin sodium hydrate 对青霉素耐药性的金黄色葡萄球菌Staphylococcus aureu 和表皮葡萄球菌Staphylococcus epidermidis 有活性。Methcillin sodium hydrate 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。

化合物

Cat.No: TP1948

Synonym: PBP 10

Cat.No: T33894

Synonym: PBP-2,PBP 2

Cat.No: T33893

Synonym: PBP-1,PBP 1

PBP 10 acetate(794466-43-6 Free base)

Cat.No: TP1948L

Cat.No: T78306

Synonym: PBP1510

Cefmetazole sodium

Cat.No: T1070

Synonym: 头孢美唑钠,Sodium cefmetazole

Target: Antibacterial, Antibiotic

RhB-PBP10 TFA

Cat.No: T81279

Cat.No: T75811

Cat.No: T22513

Target: Sigma receptor, NMDAR

Amoxicillin trihydrate

Cat.No: T1005L

Synonym: Amoxycillin trihydrate,Amoxil trihydrate,Amoxipen trihydrate,阿莫西林三水物,Moxaline trihydrate

Target: Antibacterial, Antibiotic

Cefazolin sodium

Cat.No: T0953

Synonym: Ancef,头孢唑啉钠,头孢唑林钠,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin

Target: Others, Antibacterial, Antibiotic

Cephalothin sodium

Cat.No: T1122

Synonym: 头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin

Target: Antibacterial, Antibiotic

Cat.No: T12166

Synonym: OP0595 free acid,那库巴坦

Target: Antibacterial

Tebipenem pivoxil hydrochloride

Cat.No: T75288

Cat.No: T81157

Cat.No: T61204

Methicillin sodium hydrate

Cat.No: T73859

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00169	PBP 3 Protein, Bacillus subtilis, Recombinant (His)	Bacillus subtilis	E. coli
	Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Probably required for both cortical and vegetative peptidoglycan synthesis. Although not usually required for cell division, in the absence of PBP 2B (pbpB) it becomes essential. Confers resistance to oxacillin and cephalexin. PBP 3 Protein, Bacillus subtilis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.2 kDa and the accession number is P429...
TMPH-00170	PBP 4 Protein, Bacillus subtilis, Recombinant (His & SUMO)	Bacillus subtilis	E. coli
	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (Probable). Has a partially redundant function with PBP-2A (pbpA) during spore outgrowth. PBP 4 Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N...
TMPH-00171	PBP 4A Protein, Bacillus subtilis, Recombinant (His & SUMO)	Bacillus subtilis	E. coli
	Probably involved in peptidoglycan modification during cortex synthesis. PBP 4A Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.4 kDa and the accession number is P32959.
TMPY-00146	RKIP/PEBP1 Protein, Human, Recombinant PBP,HEL-S-34,PEBP,RKIP,HCNP,PEBP-1,phosphatidyletha...	Human	E. coli
	Phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that monitor cell proliferation and differentiation. PEBP1 in many cells interacts with several pathways, namely MAPK, GRK2, NF-small ka, CyrillicB, etc. that keeps the cell proliferation and differentiation in check. This protein is expressed by many cells in humans, including neurons w...
TMPJ-00760	CXCL7 Protein, Human, Recombinant SCYB7,C-X-C Motif Chemokine 7,Leukocyte-Derived Growth Facto...	Human	E. coli
	Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basi...
TMPY-00469	CXCL7 Protein, Human, Recombinant (His) LA-PF4,TC1,LDGF,NAP-2,TGB,CTAP-III,PBP,Beta-TG,CTAP...	Human	E. coli
	CXCL7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 9.9 kDa and the accession number is P02775.
TMPH-03044	PBP1a Protein, MenB, Recombinant (His & SUMO)	MenB	E. coli
	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
TMPH-00407	PBP1a Protein, Clostridium botulinum, Recombinant (His & SUMO)	Clostridium botulinum	E. coli
	PBP1a Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00701	PBP1b Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). PBP1b Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.6 kDa and the accession number is P02919...

重组蛋白

PBP 3 Protein, Bacillus subtilis, Recombinant (His)

Cat.No: TMPH-00169

Species: Bacillus subtilis

Expression System: E. coli

PBP 4 Protein, Bacillus subtilis, Recombinant (His & SUMO)

Cat.No: TMPH-00170

Species: Bacillus subtilis

Expression System: E. coli

PBP 4A Protein, Bacillus subtilis, Recombinant (His & SUMO)

Cat.No: TMPH-00171

Species: Bacillus subtilis

Expression System: E. coli

RKIP/PEBP1 Protein, Human, Recombinant

Cat.No: TMPY-00146

Species: Human

Expression System: E. coli

CXCL7 Protein, Human, Recombinant

Cat.No: TMPJ-00760

Species: Human

Expression System: E. coli

CXCL7 Protein, Human, Recombinant (His)

Cat.No: TMPY-00469

Species: Human

Expression System: E. coli

PBP1a Protein, MenB, Recombinant (His & SUMO)

Cat.No: TMPH-03044

Species: MenB

Expression System: E. coli

PBP1a Protein, Clostridium botulinum, Recombinant (His & SUMO)

Cat.No: TMPH-00407

Species: Clostridium botulinum

Expression System: E. coli

PBP1b Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00701

Species: E. coli

Expression System: E. coli

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