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Cat. No. | Product Name | Target | Signaling Pathways |
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T35889 |
PB2
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PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1]. | |||
T39176 |
PB28
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PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (σ2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist of the sigma 1 (σ1) receptor, with a Ki of 0.38 nM. PB28 demonstrates a lower affinity for other receptors. It effectively inhibits electrically evoked twitch in both the guinea pig bladder (EC50 value of 2.62 μM) and ileum (EC50 value of 3.96 μM). Moreover, PB28 exhibits the abi... | |||
T23122 |
PB28 dihydrochloride
PB 28 dihydrochloride |
Others | Others |
σ2 receptor agonist | |||
T4377 |
Pimodivir
VX-787 |
Influenza Virus | Microbiology/Virology |
Pimodivir (VX-787) 是一种通过口服的甲型流感病毒聚合酶抑制剂,与病毒 PB2 亚基相互作用。 | |||
T12526 |
PP7
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Influenza Virus | Microbiology/Virology |
PP7 是一种PB1-PB2互作抑制剂,IC50为 8.6 μM。PB1-PB2 抑制病毒聚合酶的活性,IC50为9.5 μM。它对甲型流感病毒 A 包括 (H1N1)pdm09 (EC50=1.4 μM),A(H7N9),A(H9N2) 亚型具有抗病毒活性。 | |||
T83251 |
7-51A
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Influenza Virus | Microbiology/Virology |
7-51A为一有效PB2抑制剂,其通过ITC测定的KD值仅为1.64 nM;PB2为流感RNA依赖性RNA聚合酶(RdRP)的关键亚基。 | |||
T4377L |
Pimodivir HCl
Pimodivir hydrochloride hemihydrate,Pimodivir hydrochloride |
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Pimodivir is an inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. The cell-based EC50 for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay. VX-787 is active against a diverse | |||
T70207 |
Pimodivir tosylate
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Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T36734 |
Methyl brevifolincarboxylate
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Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultane... |