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Cat. No. Product Name Target Signaling Pathways
T8917 PAR-2-IN-1

IUN76750,8-(叔丁基)-6-氯咪唑并[1,2-B]吡啶-2-羧酸甲酯

Protease-activated Receptor GPCR/G Protein
PAR-2-IN-1 (IUN76750) 是一种 PAR-​2 信号通路抑制剂,具有抗炎和抗癌作用。
T36531 PAR2 (1-6) (mouse, rat)

PAR2 (1-6) (mouse, rat)

PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6) induces relaxation in precontracted rat arteries in a concentration-dependent manner, an effect that can be reduced by the nitric oxide synthase inhibitor L-NNA . It inhibits keratinocyte growth i...
T35955 PAR2 (1-6) amide (human) (trifluoroacetate salt)

PAR2 (1-6) amide (human) (trifluoroacetate salt)

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide prod...
T76650 PAR-2 (1-6) (human)

PAR-2 (1-6) (human) (SLIGKV) 是 PAR-2的多肽激动剂。
T36286 Protease-Activated Receptor-3 (PAR-3) (1-6), human

TFRGAP-amide, human PAR-3-derived tethered ligand sequence which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells.
T80240 Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2是一类具有生物活性的肽,作为蛋白酶激活受体1 (PAR-1) 的选择性激动剂,其特异性优于PAR-2。该肽通过HEK293细胞进行的基于细胞的钙信号传导测定确认了其对PAR-1的高特异性,并可用于研究PAR-1在体内的激活。PAR-1除了介导凝血酶的多种细胞作用外,还与PAR-4协作,参与调控凝血酶诱导的被分类为“凝血型”的肝细胞癌。
T36293 PAR 4 (1-6)

PAR 4 (1-6) 可用于生命科学领域的相关研究。其产品编号为 T36293,CAS号为 225779-44-2
T74266 Protease-Activated Receptor-1 antagonist 2

Protease-Activated Receptor-1 antagonist 2 是一种选择性蛋白酶激活受体-1 (PAR-1) 拮抗剂,口服活性,IC50值为7 nM。该化合物具有优良的药代动力学特性,适用于心血管疾病 (CVD) 如动脉粥样硬化和再狭窄的研究。
T36717 RWJ-56110 dihydrochloride

RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

PAR-2-IN-1
Cat.No: T8917
Synonym: IUN76750,8-(叔丁基)-6-氯咪唑并[1,2-B]吡啶-2-羧酸甲酯
Target: Protease-activated Receptor
PAR2 (1-6) (mouse, rat)
Cat.No: T36531
Synonym: PAR2 (1-6) (mouse, rat)
Target:
PAR2 (1-6) amide (human) (trifluoroacetate salt)
Cat.No: T35955
Synonym: PAR2 (1-6) amide (human) (trifluoroacetate salt)
Target:
PAR-2 (1-6) (human)
Cat.No: T76650
Synonym:
Target:
Protease-Activated Receptor-3 (PAR-3) (1-6), human
Cat.No: T36286
Synonym:
Target:
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
Cat.No: T80240
Synonym:
Target:
PAR 4 (1-6)
Cat.No: T36293
Synonym:
Target:
Protease-Activated Receptor-1 antagonist 2
Cat.No: T74266
Synonym:
Target:
RWJ-56110 dihydrochloride
Cat.No: T36717
Synonym:
Target:
TargetMol Loading
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