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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8533	ML318	Others; Antibiotic	Microbiology/Virology; Others
	ML318 是 PvdQ 酰基转移酶的联芳基腈抑制剂，可以结合在酰基结合位点上，IC50为 20 nM。它抑制铜绿假单胞菌的 IC50为 19 μM。它可防止嘧啶的产生并限制了铜绿假单胞菌在铁限制条件下的生长。
T61108	YXL-13
	YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13 significantly diminishes both the pathogenicity and drug resistance of PAO1 by inhibiting the quorum sensing (QS) system. Thus, YXL-13 holds great potential for studying antibacterial properties [1].
T13395L	Zidebactam 齐德巴坦,WCK-5107	Antibacterial	Microbiology/Virology
	Zidebactam (WCK-5107) 是一种β-内酰胺酶抑制剂。它也是一种青霉素结合蛋白 2 抑制剂，IC50值为 0.26 μg/ml。
T37464	CAY10711
	CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef...
T83738	SMAP 29 (ovine) TFA Sheep Myeloid Antimicrobial Peptide 29
	SMAP 29是一种抗微生物肽，同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下，对P. aeruginosa菌株PAO1具有杀菌作用，该作用在能量依赖的发光测定中表现出来（EC50s分别为0.05和0.06 µM）。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。
T78935	Quorum Sensing-IN-2
	Quorum Sensing-IN-2（compound 23e）是一款不影响细菌生长的群体感应抑制剂，具有减少细菌致病性的功能。该化合物在抑制细菌感染方面表现出效力，同时具有极低的溶血活性。在铜绿假单胞菌PAO1引起的菌血症模型中，Quorum Sensing-IN-2与环丙沙星共同作用，显示了协同效应。

化合物

ML318

Cat.No: T8533

Synonym:

Target: Others, Antibiotic

Synonym: 齐德巴坦,WCK-5107

Target: Antibacterial

Synonym: Sheep Myeloid Antimicrobial Peptide 29

Cat. No.	Product Name	Target	Signaling Pathways
T37341	N-Acetyltyramine	Antibacterial	Microbiology/Virology
	N-Acetyltyramine 是一种群体感应抑制剂，由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。