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Cat. No.	Product Name	Target	Signaling Pathways
T9127	MYLS22	Others	Others
	MYLS22 是视神经萎缩 1 的选择性抑制剂。它通过影响 NFkB 活性和血管生成基因表达抑制血管生成，靶向作用于内皮细胞 OPA1 ，减少肿瘤的生长。
T37023	MB 0223
	Dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion. Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID:29601815
T78875	BTM-3528	Mitochondrial Metabolism	Metabolism
	BTM-3528是一种线粒体蛋白酶OMA1的激活剂，能够过度激活线粒体整合应激反应(ISR)。该化合物促进了OMA1依赖的DELE1和OPA1的裂解，导致线粒体断裂。此外，BTM-3528通过激活eIF2α激酶HRI，引发细胞生长停滞及apoptosis。在多种DLBCL细胞系中表现出抗癌活性，且在异种移植人DLBCL SU-DHL-10细胞小鼠模型中显示出明显的体内抑制作用。
T36490	AZT triphosphate TEA
	AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in ...