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4

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35513	13C15-Nivalenol 13C15-Nivalenol
	13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026...
T35517	4-deoxy Nivalenol-13C15 4-deoxy Nivalenol-13C15
	4-deoxy Nivalenol-13C15is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2It induces leth...
T35515	3-Acetyldeoxy Nivalenol-13C17 3-Acetyldeoxy Nivalenol-13C17
	3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami...
T31360	Deepoxy-deoxynivalenol DOM-I,DOM-1
	Deepoxy-deoxynivalenol is Metabolite of deoxynivalenol. Deepoxydeoxynivalenol is a macrocyclic polyol compound for proteomics research. Environmental contaminants; Food contaminants.

化合物

13C15-Nivalenol

Cat.No: T35513

Synonym: 13C15-Nivalenol

4-deoxy Nivalenol-13C15

Cat.No: T35517

Synonym: 4-deoxy Nivalenol-13C15

3-Acetyldeoxy Nivalenol-13C17

Cat.No: T35515

Synonym: 3-Acetyldeoxy Nivalenol-13C17

Deepoxy-deoxynivalenol

Cat.No: T31360

Synonym: DOM-I,DOM-1

Cat. No.	Product Name	Target	Signaling Pathways
T13797	Nivalenol	Caspase	Apoptosis; Proteases/Proteasome
	Nivalenol 是一种由禾谷镰刀菌产生的真菌代谢物。 Nivalenol 通过 caspase 和内在凋亡途径诱导细胞死亡，从而影响免疫系统并引起呕吐、生长迟缓和生殖障碍。
T13493	3-Acetyldeoxynivalenol	Others	Others
	3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin.
T15097	Deoxynivalenol Vomitoxin,4-Deoxynivalenol
	Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。
T10045	15-Acetyl-deoxynivalenol	Others	Others
	15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells.

天然产物

Cat.No: T13797

Target: Caspase

3-Acetyldeoxynivalenol

Cat.No: T13493

Target: Others

Cat.No: T15097

Synonym: Vomitoxin,4-Deoxynivalenol

15-Acetyl-deoxynivalenol

Cat.No: T10045

Target: Others

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