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Cat. No. | Product Name | Target | Signaling Pathways |
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TP1363 |
Neurokinin B
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Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone. | |||
TP1363L |
Neurokinin B acetate(86933-75-7 free base)
神经激肽 B醋酸盐,Neurokinin K |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Neurokinin B acetate(86933-75-7 free base) 是属于速激肽家族的神经激肽 B 的醋酸盐形式。神经激肽与神经激肽受体 1 (NK1R)、nk2r 和 NK3R 结合,并介导其生物学效应。 | |||
TP1279 |
Neurokinin B (TFA)
神经激肽 B 三氟乙酸盐,Neurokinin B TFA |
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Neurokinin B TFA belongs to the tachykinin family.Neurokinin B binds to a series of GPCR, including neurokinin receptors 1 (NK1R), NK2R, and nk3r, to modulate their biological effects | |||
T16849 |
SB-222200
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Neurokinin receptor | GPCR/G Protein; Neuroscience |
SB-222200 是一种选择性口服活性的,具有血脑屏障渗透性的 NK-3 受体拮抗剂,用于中枢神经系统疾病的研究。 | |||
T80914 |
Tyr0-Neurokinin B
Tyr-NKB |
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Tyr0-Neurokinin B (Tyr-NKB)为Neurokinin B的类似物,具有引发膀胱收缩的生物活性。 | |||
T76436 |
[MePhe7]-Neurokinin B
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[MePhe7]-Neurokinin B为NK-3受体(NK3R)激动剂,具有3 nM的IC50值。通过激活神经激肽3受体,[MePhe7]-Neurokinin B能够调节脉冲促性腺激素释放激素(GnRH)的分泌,成为调控该过程的潜在调节剂。 | |||
T76427 |
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B
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(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 是 Neurokinin B(Neurokinin Receptor) 的竞争性拮抗剂,pA2 为 5.5,对 Substance P 或 Neurokinin A 没有影响。 | |||
T24285 |
L 363851
L363851,L-363851,L363,851,L 363,851,L-363,851 |
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L 363851 is a neurokinin B agonist. | |||
T76431 |
GR 83074
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GR 83074 是一种有效的选择性 NK-2(Neurokinin Receptor) 拮抗剂,pKB 为 8.23。GR 83074 对 NK-3 没有活性,并表现出 340 倍的 NK-2/NK-1 选择性。 | |||
T38276 |
Benzomalvin C
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Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E. | |||
T36053 |
D-Lysine lactam
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D-Lysine lactam is a chiral building block.1,2It has been used in the synthesis of a chiral antibiotic synthetic intermediate, as well as in the stereoselective synthesis of neurokinin (NK) receptor antagonists. 1.Kumar, A., Bhashkar, B., Bhavsar, J., et al.Catalytic reduction: Efficient synthesis of chiral key intermediate of besifloxacin hydrochlorideDer Pharma Chemica7(9)297-3000(2015) 2.Gerspacher, M., Lewis, C., Ball, H.A., et al.Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobe... | |||
T32007 |
GSK256471
GSK 256471,GSK-256471 |
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GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment showed that GSK256471 reduced the E(Ma |
Cat. No. | Product Name | Target | Signaling Pathways |
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T38033 |
Benzomalvin B
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Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml. |