Cat. No. | Product Name | Target | Signaling Pathways |
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T15431 |
Nemiralisib
GSK2269557 (free base),GSK2269557 |
PI3K | PI3K/Akt/mTOR signaling |
Nemiralisib(GSK-2269557 free base)是一种可口服且具有有效性和特异性的 PI3Kδ 抑制剂,pKi 为 9.9。Nemiralisib 可用于治疗包括慢性阻塞性肺疾病在内的呼吸系统疾病。 | |||
T70858 |
Nemiralisib succinate
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Nemiralisib succinate is a potent and selective PI3Kδ inhibitor. | |||
T70856 |
3-Oxobetulin Acetate
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3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto... |