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6

抑制剂 & 化合物

11

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T62727 NRP1 antagonist 1

NRP1 antagonist 1 (compound 12a) 是一种 NRP1 的有效拮抗剂 (IC50: 19.1 μM)。NRP1 antagonist 1 具有潜力进行癌症研究的研究。
T62845 NRP1 antagonist 2

NRP1 antagonist 2 (Compound 1) 是一种 NRP1 拮抗剂。
T37424 CAY10781

CAY10781

Others Others
CAY10781 是一种神经纤毛蛋白-1 (NRP-1) 和 VEGF-A.1 之间蛋白质-蛋白质相互作用的抑制剂。当使用浓度为 12.5 μM 时,它可抑制 43% 的相互作用。 当以相同浓度使用时,CAY10781 还抑制 VEGF-A 诱导的儿茶酚胺 A 分化 (CAD) 细胞中 VEGFR2 的磷酸化。
T76879 Vesencumab

Vesencumab (MNRP-1685A)是一种针对neuropilin-1 (NRP-1)的IG1抗体。通过与NRP-1结合,Vesencumab 阻断了NRP-1与VEGFR-2的偶联,展现出抗血管生成和抗肿瘤的活性。此化合物适用于转移性实体瘤,如卵巢癌的研究。
T10408 ATWLPPR Peptide TFA

Others Others
ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes.
T76255 Certepetide

Certepetide (CEND-1),即双功能环肽(a.k.a. iRGD),是一种具有穿透肿瘤功能的多肽。通过与α-V整联蛋白(alphav-integrins)的RGD motif相互作用,以及激活神经纤毛蛋白1(NRP-1),Certepetide能够将实体瘤微环境转化成临时的活性分子通道,从而在肿瘤中累积。该化合物在胰腺癌和其他实体瘤的研究中具有应用潜力。

化合物

NRP1 antagonist 1
Cat.No: T62727
Synonym:
Target:
NRP1 antagonist 2
Cat.No: T62845
Synonym:
Target:
CAY10781
Cat.No: T37424
Synonym: CAY10781
Target: Others
Vesencumab
Cat.No: T76879
Synonym:
Target:
ATWLPPR Peptide TFA
Cat.No: T10408
Synonym:
Target: Others
Certepetide
Cat.No: T76255
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-02367 Neuropilin-1 Protein, Human, Recombinant (isoform b, His)

neuropilin 1,NRP,VEGF165R,BDCA4,Neuropilin-1,NP1,CD...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2.
TMPY-05740 Neuropilin-1 Protein, Mouse, Recombinant (His)

neuropilin 1,Npn1,Nrp,NP-1,NPN-1,C530029I03

Mouse HEK293 Cells
Neuropilin-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95.12 kDa and the accession number is P97333.
TMPY-00891 Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BD...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPY-01692 NETO1 Protein, Human, Recombinant (His)

neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTC...

Human HEK293 Cells
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr...
TMPY-03501 Optineurin Protein, Human, Recombinant (His & GST)

optineurin,HIP7,ALS12,HYPL,TFIIIA-INTP,FIP2,NRP,GLC...

Human Baculovirus Insect Cells
OPTN (Optineurin) is a Protein Coding gene. The Optineurin gene encodes the coiled-coil containing protein optineurin. Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomerization, optineurin can act as an adaptor, scaffold, or signal regulator to coordinate many cellular processes associated with the ...
TMPY-05519 Neuropilin-1 Protein, Mouse, Recombinant (mFc)

NPN-1,neuropilin 1,Nrp,C530029I03,NP-1,Npn1

Mouse HEK293 Cells
Neuropilin-1 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 120 kDa and the accession number is P97333.
TMPY-06477 Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His)

NRP,neuropilin 1,CD304,VEGF165R,Neuropilin-1,BDCA4,...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.31 kDa and the accession number is NP_001019799.2.
TMPY-05585 Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated

CD304,BDCA4,neuropilin 1,NRP,Neuropilin-1,NP1,VEGF1...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 73.1 kDa and the accession number is O14786-2.
TMPY-06370 Neuropilin-1 Protein, Human, Recombinant (His)

BDCA4,NRP,neuropilin 1,Neuropilin-1,VEGF165R,CD304,...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.33 kDa and the accession number is NP_001019799.2.
TMPY-02682 NELL2 Protein, Human, Recombinant (His)

NEL-like 2 (chicken),NRP2

Human Baculovirus Insect Cells
A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in the mammal. NELL2 is an abundant glycoprotein containing an EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytos...
TMPJ-00355 Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated

CD304,VEGF165R,NRP1,NRPNP1,BDCA4

Human HEK293 Cells
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds ...

重组蛋白

Neuropilin-1 Protein, Human, Recombinant (isoform b, His)
Cat.No: TMPY-02367
Species: Human
Expression System: HEK293 Cells
Neuropilin-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-05740
Species: Mouse
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
Cat.No: TMPY-00891
Species: Human
Expression System: HEK293 Cells
NETO1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01692
Species: Human
Expression System: HEK293 Cells
Optineurin Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-03501
Species: Human
Expression System: Baculovirus Insect Cells
Neuropilin-1 Protein, Mouse, Recombinant (mFc)
Cat.No: TMPY-05519
Species: Mouse
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His)
Cat.No: TMPY-06477
Species: Human
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPY-05585
Species: Human
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (His)
Cat.No: TMPY-06370
Species: Human
Expression System: HEK293 Cells
NELL2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02682
Species: Human
Expression System: Baculovirus Insect Cells
Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated
Cat.No: TMPJ-00355
Species: Human
Expression System: HEK293 Cells
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