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Cat. No. | Product Name | Target | Signaling Pathways |
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T62727 | NRP1 antagonist 1 | ||
NRP1 antagonist 1 (compound 12a) 是一种 NRP1 的有效拮抗剂 (IC50: 19.1 μM)。NRP1 antagonist 1 具有潜力进行癌症研究的研究。 | |||
T62845 | NRP1 antagonist 2 | ||
NRP1 antagonist 2 (Compound 1) 是一种 NRP1 拮抗剂。 | |||
T37424 |
CAY10781
CAY10781 |
Others | Others |
CAY10781 是一种神经纤毛蛋白-1 (NRP-1) 和 VEGF-A.1 之间蛋白质-蛋白质相互作用的抑制剂。当使用浓度为 12.5 μM 时,它可抑制 43% 的相互作用。 当以相同浓度使用时,CAY10781 还抑制 VEGF-A 诱导的儿茶酚胺 A 分化 (CAD) 细胞中 VEGFR2 的磷酸化。 | |||
T76879 | Vesencumab | ||
Vesencumab (MNRP-1685A)是一种针对neuropilin-1 (NRP-1)的IG1抗体。通过与NRP-1结合,Vesencumab 阻断了NRP-1与VEGFR-2的偶联,展现出抗血管生成和抗肿瘤的活性。此化合物适用于转移性实体瘤,如卵巢癌的研究。 | |||
T10408 |
ATWLPPR Peptide TFA
|
Others | Others |
ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes. | |||
T76255 |
Certepetide
|
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Certepetide (CEND-1),即双功能环肽(a.k.a. iRGD),是一种具有穿透肿瘤功能的多肽。通过与α-V整联蛋白(alphav-integrins)的RGD motif相互作用,以及激活神经纤毛蛋白1(NRP-1),Certepetide能够将实体瘤微环境转化成临时的活性分子通道,从而在肿瘤中累积。该化合物在胰腺癌和其他实体瘤的研究中具有应用潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02367 |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His)
neuropilin 1,NRP,VEGF165R,BDCA4,Neuropilin-1,NP1,CD... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2. | |||
TMPY-05740 |
Neuropilin-1 Protein, Mouse, Recombinant (His)
neuropilin 1,Npn1,Nrp,NP-1,NPN-1,C530029I03 |
Mouse | HEK293 Cells |
Neuropilin-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95.12 kDa and the accession number is P97333. | |||
TMPY-00891 |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BD... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2. | |||
TMPY-01692 |
NETO1 Protein, Human, Recombinant (His)
neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTC... |
Human | HEK293 Cells |
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr... | |||
TMPY-03501 |
Optineurin Protein, Human, Recombinant (His & GST)
optineurin,HIP7,ALS12,HYPL,TFIIIA-INTP,FIP2,NRP,GLC... |
Human | Baculovirus Insect Cells |
OPTN (Optineurin) is a Protein Coding gene. The Optineurin gene encodes the coiled-coil containing protein optineurin. Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomerization, optineurin can act as an adaptor, scaffold, or signal regulator to coordinate many cellular processes associated with the ... | |||
TMPY-05519 |
Neuropilin-1 Protein, Mouse, Recombinant (mFc)
NPN-1,neuropilin 1,Nrp,C530029I03,NP-1,Npn1 |
Mouse | HEK293 Cells |
Neuropilin-1 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 120 kDa and the accession number is P97333. | |||
TMPY-06477 |
Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His)
NRP,neuropilin 1,CD304,VEGF165R,Neuropilin-1,BDCA4,... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.31 kDa and the accession number is NP_001019799.2. | |||
TMPY-05585 |
Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated
CD304,BDCA4,neuropilin 1,NRP,Neuropilin-1,NP1,VEGF1... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 73.1 kDa and the accession number is O14786-2. | |||
TMPY-06370 |
Neuropilin-1 Protein, Human, Recombinant (His)
BDCA4,NRP,neuropilin 1,Neuropilin-1,VEGF165R,CD304,... |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.33 kDa and the accession number is NP_001019799.2. | |||
TMPY-02682 |
NELL2 Protein, Human, Recombinant (His)
NEL-like 2 (chicken),NRP2 |
Human | Baculovirus Insect Cells |
A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in the mammal. NELL2 is an abundant glycoprotein containing an EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytos... | |||
TMPJ-00355 |
Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated
CD304,VEGF165R,NRP1,NRPNP1,BDCA4 |
Human | HEK293 Cells |
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds ... |