Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T73353 | NOS-IN-3 | ||
NOS-IN-3 是一个强效的、选择性的由 imidamide 衍生的NOS 抑制剂,对iNOS 的IC50值为20 µM。 NOS-IN-3 不抑制eNOS,几乎没有毒性,可用于研究治疗可诱导亚型涉及的疾病,如感染性休克。 | |||
T83625 |
iNOS-IN-14
3-bromo-1H-indazole-7-carbonitrile |
NOS | Immunology/Inflammation |
iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) 是一种有效的一氧化氮合酶(NOS)抑制剂,抑制nNOS的NADPH氧化酶活性。 | |||
T82251 |
GW274150 dihydrochloride
|
NO Synthase | Immunology/Inflammation |
GW274150 (dihydrochloride) 是高效、选择性的 NADPH 依赖型人诱导型一氧化氮合成酶 (iNOS) (Kd=40 nM) 抑制剂,具有口服活性,同时对大鼠 (iNOS) 也有效。相较于人和大鼠的内皮一氧化氮合酶 (eNOS) 及神经元一氧化氮合酶 (nNOS),其效力显著较低。GW274150 (dihydrochloride) 在急性肺损伤炎症模型中具有保护作用。 | |||
T37238 |
(±)19(20)-EpDPA
|
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic... | |||
T37234 |
(±)14(15)-EpETE
|
||
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoi... | |||
T37235 |
(±)16(17)-EpDPA
(±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA |
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex... | |||
T75339 |
Methylene blue hydrate
|
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亚甲蓝(Basic Blue 9)水合物,作为鸟苷酸环化酶(sGC)、单胺氧化酶A(MAO-A)及NO合酶(NOS)的抑制剂,常用于医疗作为血管加压剂及染料。该化合物通过影响一氧化氮合成酶/鸟苷酸环化酶信号通路,能够减少脉冲前抑制,同时作为一种氧化还原循环化合物,具有穿透血脑屏障的能力,并作为Tau蛋白聚集的抑制剂,有助于缓解脑水肿、减轻小胶质细胞活化和神经炎症。 |