Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7417 |
Avatrombopag
YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501 |
Thrombin; Thrombopoietin Receptor | Immunology/Inflammation; Proteases/Proteasome |
Avatrombopag (YM477) 是一种新型口服血小板生成素 (TPO) 受体激动剂,可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。 | |||
T78805 |
AD4
|
Others | Others |
AD4是一种青蒿素衍生的PROTACs,具有针对PCLAF的高效降解能力,在RS4;11细胞中的IC50仅为0.6 nM。通过激活p21/Rb轴,AD4展现出明显的抗肿瘤活性。此外,AD4在NOD/SCID小鼠移植的RS4;11模型中显著延长了生存时间,证实了其体内疗效。 | |||
T35675 |
SW203668 (trifluoroacetate salt)
|
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SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production... |